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In our study, we examined the miRNA expression profile of meningiomas, which is a common type of benign intracranial tumor derived from the protective meninges membranes that surround the brain and spinal cord. To define a typical human meningioma miRNA profile, the expression of 200 miRNAs in a training sample set were screened using quantitative reverse transcription polymerase chain reaction analysis, and then significantly altered miRNAs were validated in a secondary independent sample set. Kaplan\u2013Meier and univariate\/multivariate Cox proportional hazard regression analyses were performed to assess whether miRNA expression could predict the recurrence of meningioma after tumor resection. After a two\u2010phase selection and validation process, 14 miRNAs were found to exhibit significantly different expression profiles in meningioma samples compared to normal adjacent tissue (NAT) samples. Unsupervised clustering analysis indicated that the 14\u2010miRNA profile differed between tumor and NAT samples. Downregulation of miR\u201029c\u20103p and miR\u2010219\u20105p were found to be associated with advanced clinical stages of meningioma. Kaplan\u2013Meier analysis showed that high expression of miR\u2010190a and low expression of miR\u201029c\u20103p and miR\u2010219\u20105p correlated significantly with higher recurrence rates in meningioma patients. Cox proportional hazard regression analysis revealed that miR\u2010190a expression level is an important prognostic predictor that is independent of other clinicopathological factors. Our results suggest that the use of miRNA profiling has significant potential as an effective diagnostic and prognostic marker in defining the expression signature of meningiomas and in predicting postsurgical outcomes.<\/jats:p>","DOI":"10.1002\/ijc.27658","type":"journal-article","created":{"date-parts":[[2012,6,2]],"date-time":"2012-06-02T04:07:10Z","timestamp":1338610030000},"page":"128-136","source":"Crossref","is-referenced-by-count":56,"title":["A microRNA expression signature predicts meningioma 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