{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:49:26Z","timestamp":1773247766040,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T00:00:00Z","timestamp":1340668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer mortality in Chile is four times higher than in developed countries. We compared the accuracy of human papillomavirus (HPV) DNA testing and conventional Papanicolaou (Pap) testing to detect prevalent precancerous and cancerous lesions in the routine clinical practice of the public health system. Women aged 25 years and older residing in the area covered by three primary care centers of Santiago, Chile, were invited to participate. Eligible women received both HPV DNA (Hybrid Capture 2) and Pap testing. Women positive by either test (Pap: ASCUS+, HC2: RLU\/CO \u22651.0) underwent colposcopy and biopsy, as did a sample of double\u2010negative women with an abnormal cervix at visual inspection or with risk factors for cervical lesions. Crude and verification bias\u2010corrected sensitivities and specificities were estimated. In total, 8,265 women (98.8% of eligible) had complete screening results. Of these, 10.7% were HPV positive, 1.7% were Pap positive and 1.1% were positive by both tests. In all, 931 (11.3%) women were screen\u2010positive, of whom 94.3% attended colposcopy. Additionally, 295 control women were invited for colposcopy, of whom 78% attended. In all, 42 CIN2, 45 CIN3 and 9 cancers were identified. Verification bias\u2010corrected sensitivity for CIN2+ (95% confidence interval) was 92.7% (84.4\u201396.8) for HPV and 22.1% (16.4\u201329.2) for Pap; corresponding specificities were 92.0% (91.4\u201392.6) and 98.9% (98.7\u201399.0). In conclusion, in routine clinical practice in a developing country, HPV testing was four times more sensitive for CIN2+ than Pap testing, identifying three times more CIN2+ lesions; HPV testing was easily implemented in our established cervical cancer prevention program.<\/jats:p>","DOI":"10.1002\/ijc.27662","type":"journal-article","created":{"date-parts":[[2012,6,9]],"date-time":"2012-06-09T06:16:08Z","timestamp":1339222568000},"page":"916-923","source":"Crossref","is-referenced-by-count":33,"title":["Screening trial of human papillomavirus for early detection of cervical cancer in Santiago, Chile"],"prefix":"10.1002","volume":"132","author":[{"given":"Catterina","family":"Ferreccio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Barriga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Lagos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Poggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solana","family":"Terrazas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hormuzd A.","family":"Katki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Cartagena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Van De Wyngard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daysi","family":"Vi\u00f1ales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Bra\u00f1es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Chile Ministry of Health Departamento de Estad\u00edsticas e Informaci\u00f3n de Salud. Mortalidad.http:\/\/www.deis.cl\/estadisticas\u2010mortalidad\/(in Spanish; accessed Dec 12 2011)."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61351-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.10.818"},{"key":"e_1_2_6_7_2","first-page":"815","article-title":"A comparison of single and combined visual, cytological, and virologic tests as screening strategies in a region at high risk of cervical cancer","volume":"12","author":"Ferreccio C","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25071"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2005.07.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60038-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114580"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4422"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24774"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013711"},{"key":"e_1_2_6_17_2","unstructured":"Chile Ministry of Health Departamento de Estad\u00edsticas e Informaci\u00f3n de Salud. Cobertura.http:\/\/www.deis.cl\/cobertura\/(in Spanish; accessed March 26 2012)."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001120)89:6<529::AID-IJC11>3.0.CO;2-G"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22757"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23489"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14955-0"},{"key":"e_1_2_6_23_2","unstructured":"Instituto Nacional de Estadisticas de Chile. Censo de Poblacion y Vivienda 1992 2002. http:\/\/www.ine.cl\/canales\/usuarios\/censos_digitalizados.php (in Spanish; accessed December 12 2011)."},{"key":"e_1_2_6_24_2","first-page":"1","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Schiffman M","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_25_2","unstructured":"The World Bank. World Development Indicators & Global Development Finance database Chile GDP per capita constant 2000 US$ 1990\u20132010.http:\/\/databank.worldbank.org(in Spanish; accessed December 12 2011)."},{"key":"e_1_2_6_26_2","unstructured":"Instituto Nacional de Estad\u00edsticas de Chile. Evolucion de la Mortalidad en Chile segun causas de muerte y edad 1990\u20132007.http:\/\/www.ine.cl\/canales\/menu\/publicaciones\/calendario_de_publicaciones\/pdf\/010211\/evo90_07_010211.pdf(in Spanish; accessed March 26 2012)."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.013"},{"key":"e_1_2_6_28_2","unstructured":"OECD.Society at a Glance 2011: OECD Social Indicators.OECD Publishing2011; page67."},{"key":"e_1_2_6_29_2","unstructured":"The World Bank. Indicator: GINI index.http:\/\/data.worldbank.org\/indicator\/SI.POV.GINI(accessed December 12 2011)."},{"key":"e_1_2_6_30_2","unstructured":"Chile Ministry of Social Development.Encuesta CASEN 1990 2009 database."},{"key":"e_1_2_6_31_2","unstructured":"OECD. Health at a Glance 2011: OECD Indicators. OECD Publishing2011; page119."},{"key":"e_1_2_6_32_2","unstructured":"Chile Ministry of Health Departamento de Estad\u00edsticas e Informaci\u00f3n de Salud. Natalidad. http:\/\/www.deis.cl\/estadisticas\u2010natalidad\/ (in Spanish; accessed March 26 2012)."},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.167"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.022"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70188-7"},{"key":"e_1_2_6_36_2","first-page":"1261","article-title":"Sexual behavior and gender differences among adolescents consulting at a university public health system","volume":"135","author":"Gonz\u00e1lez E","year":"2007","journal-title":"Rev M\u00e9d Chile"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1258\/0969141054855328"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.11.004"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.27662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.27662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T19:45:33Z","timestamp":1697485533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.27662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,26]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2,15]]}},"alternative-id":["10.1002\/ijc.27662"],"URL":"https:\/\/doi.org\/10.1002\/ijc.27662","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,26]]}}}