{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:39:36Z","timestamp":1789231176090,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined incidence probabilities of cervical intraepithelial neoplasia 3 (CIN3) or more severe lesions (CIN3+) in 1,467 adult Japanese women with abnormal cytology in relation to seven common human papillomavirus (HPV) infections (16\/18\/31\/33\/35\/52\/58) between April 2000 and March 2008. Sixty\u2010seven patients with multiple HPV infection were excluded from the risk factor analysis. Incidence of CIN3+ in 1,400 patients including 68 with ASCUS, 969 with low grade squamous intraepithelial lesion (LSIL), 132 with HSIL without histology\u2010proven CIN2 (HSIL\/CIN2(\u2212)) and 231 with HSIL with histology\u2010proven CIN2 (HSIL\/CIN2(+)) was investigated. In both high grade squamous intraepithelial lesion (HSIL)\/CIN2(\u2212) and HSIL\/CIN2(+), HPV16\/18\/33 was associated with a significantly earlier and higher incidence of CIN3+ than HPV31\/35\/52\/58 (<jats:italic>p<\/jats:italic> = 0.049 and <jats:italic>p<\/jats:italic> = 0.0060, respectively). This association was also observed in LSIL (<jats:italic>p<\/jats:italic> = 0.0002). The 1\u2010year cumulative incidence rate (CIR) of CIN3+ in HSIL\/CIN2(\u2212) and HSIL\/CIN2(+) according to HPV genotypes (16\/18\/33 <jats:italic>vs<\/jats:italic>. 31\/35\/52\/58) were 27.1% <jats:italic>vs<\/jats:italic>. 7.5% and 46.6% <jats:italic>vs<\/jats:italic>. 19.2%, respectively. In contrast, progression of HSIL\/CIN2(+) to CIN3+ was infrequent when HPV DNA was undetected: 0% of 1\u2010year CIR and 8.1% of 5\u2010year CIR. All cervical cancer occurred in HSIL cases of seven high\u2010risk HPVs (11\/198) but not in cases of other HPV or undetectable\/negative\u2010HPV (0\/165) (<jats:italic>p<\/jats:italic> = 0.0013). In conclusion, incidence of CIN3+ depends on HPV genotypes, severity of cytological abnormalities and histology of CIN2. HSIL\/CIN2(+) associated with HPV16\/18\/33 may justify early therapeutic intervention, while HSIL\/CIN2(\u2212) harboring these HPV genotypes needs close observation to detect incidence of CIN3+. A therapeutic intervention is not indicated for CIN2 without HPV DNA.<\/jats:p>","DOI":"10.1002\/ijc.27680","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T19:59:25Z","timestamp":1340395165000},"page":"327-334","source":"Crossref","is-referenced-by-count":23,"title":["Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women"],"prefix":"10.1002","volume":"132","author":[{"given":"Masayoshi","family":"Hosaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon 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