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More than 6,000 women diagnosed with HG\u2010CIN or ICC from 17 European countries were enrolled in two parallel cross\u2010sectional studies (108288\/108290). Centralised histopathology review and standardised HPV\u2010DNA typing were applied to formalin\u2010fixed paraffin\u2010embedded cervical specimens dated 2001\u20132008. The pooled prevalence of individual HPV types was estimated using meta\u2010analytic methods. A total of 3,103 women were diagnosed with HG\u2010CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV\u2010positive, respectively. The most common HPV types in women with HG\u2010CIN were HPV16\/33\/31 (59.9\/10.5\/9.0%) and in ICC were HPV16\/18\/45 (63.3\/15.2\/5.3%). In squamous cell carcinomas, HPV16\/18\/33 were most frequent (66.2\/10.8\/5.3%), and in adenocarcinomas, HPV16\/18\/45 (54.2\/40.4\/8.3%). The prevalence of HPV16\/18\/45 was 1.1\/3.5\/2.5 times higher in ICC than in HG\u2010CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31\/33\/\u2018other\u2019 (23\/20\/17 years), and for HPV45 (1 year) than HPV16\/31\/33\/\u2018other\u2019 (15\/23\/20\/17 years). In Europe, HPV16 predominates in both HG\u2010CIN and ICC, whereas HPV18\/45 are associated with a low median age of ICC. HPV18\/45 are more frequent in ICC than HG\u2010CIN and associated with a high median age of HG\u2010CIN, with a narrow age interval between HG\u2010CIN and ICC detection. These findings support the need for primary prevention of HPV16\/18\/45\u2010related cervical lesions.<\/jats:p>","DOI":"10.1002\/ijc.27713","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T06:33:10Z","timestamp":1341297190000},"page":"854-867","source":"Crossref","is-referenced-by-count":186,"title":["Differences in human papillomavirus type distribution in high\u2010grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe"],"prefix":"10.1002","volume":"132","author":[{"given":"Wiebren A.","family":"Tjalma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Fiander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej M.","family":"Nowakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O'Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar A.","family":"Joura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Rosenlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Colau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Schledermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kersti","family":"Kukk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileia","family":"Damaskou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Repanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Vladareanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Kolomiets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alevtina","family":"Savicheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Shipitsyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Ordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anco","family":"Molijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Quint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Raillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Rosillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Collas","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsiaryna","family":"Holl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the HERACLES\/SCALE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"IARC. 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