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We analyzed data from the Australian National Endometrial Cancer Study (ANECS), a population\u2010based case\u2013control study (1,398 cases, 740 controls). We systematically reviewed all the evidence linking aspirin\/NSAIDs use with endometrial cancer and conducted a meta\u2010analysis. For ANECS, unconditional logistic regression was used to estimate odds ratios (OR) adjusting for potential confounders. For the systematic review, we searched Pubmed, Embase, Web of Science and conducted a review of citations from retrieved articles. The meta\u2010analysis risk estimates were pooled using a random\u2010effects model. In our case\u2013control study, women who had ever used aspirin in the last 5 years had a significantly lower risk of endometrial cancer OR = 0.78 [95% confidence interval (CI): 0.63\u20100.97]. There was a significant inverse dose\u2013response (<jats:italic>p\u2010<\/jats:italic>trend &lt;0.001) such that women who reported using \u22652 aspirin\/week had almost half the risk OR = 0.54 (0.38\u20130.78). No significant associations were observed between use of half\u2010aspirin\/day, non\u2010aspirin NSAIDs or paracetamol and endometrial cancer risk. The results were similar when examined by cancer subtype. Nine studies were included in the meta\u2010analysis. The overall pooled risk estimate for any<jats:italic>versus<\/jats:italic>no use of aspirin was 0.87 (0.79\u20130.96) with no evidence of heterogeneity. The pooled risk estimate for obese women (BMI \u2265 30 kg\/m<jats:sup>2<\/jats:sup>) was 0.72 (0.58\u20130.90) but there was no association for non\u2010obese women. Overall these results suggest that aspirin may reduce the risk of endometrial cancer, particularly among obese women.<\/jats:p>","DOI":"10.1002\/ijc.27717","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T09:49:44Z","timestamp":1341827384000},"page":"1146-1155","source":"Crossref","is-referenced-by-count":61,"title":["Aspirin, nonsteroidal anti\u2010inflammatory drugs, paracetamol and risk of endometrial cancer: A case\u2013control study, systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"132","author":[{"given":"Annette S.","family":"Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Nagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda M.","family":"Protani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Obermair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B.","family":"Spurdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Australian National Endometrial Cancer Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ijc.25050","article-title":"Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition","volume":"127","author":"Dossus L","year":"2009","journal-title":"Int J Cancer"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0180"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0493"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-10-0072"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1943"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1063"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(10)70262-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.289"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70035-X"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32833b4871"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0239"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0936"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0457"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0976"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199403000-00003"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp321"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6257"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/317520"},{"key":"e_1_2_7_21_2","volume-title":"World Health Organization Classification of Tumours. 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