{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:15:05Z","timestamp":1761988505465},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010grade squamous intraepithelial lesion (LSIL) is a common cytologic finding in cervical screening, yet only about 10\u201320% have significant histologic abnormalities and these are almost always positive for high\u2010risk human papillomavirus (hrHPV). This analysis aims to clarify the role of hrHPV DNA testing in the triage of women with LSIL cytology. In the ATHENA screening trial, we examined 1,084 cases of LSIL, of which 925 had an evaluable biopsy, to determine the extent to which hrHPV testing can identify those patients who have precursor lesions in need of immediate clinical referral and those who have changes more likely to regress spontaneously. Overall, 71.2% of LSIL cases were hrHPV positive, but the prevalence was age dependent, with only 56.1% in women \u226540 years. Among women with LSIL, 11.6% (107\/925) had a cervical intraepithelial neoplasia grade 2 or worse (CIN2+) histologic diagnosis and, of these, only nine were hrHPV negative. For CIN3+, 91.7% (44\/48) of women with LSIL were hrHPV positive. The negative predictive value of hrHPV testing for CIN3+ in LSIL was 100% for women aged \u226540 years. Women who were HPV16 positive had a higher positive predictive value for CIN2+ (25.4%) than those who were positive for 12 other pooled hrHPV types (11.5%). Testing for hrHPV in women with LSIL is effective in identifying high\u2010grade cervical lesions, thereby avoiding unnecessary referrals to colposcopy and potential over\u2010treatment of non\u2010progressive lesions, especially for women aged \u226540 years.<\/jats:p>","DOI":"10.1002\/ijc.27723","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T05:20:47Z","timestamp":1342675247000},"page":"959-966","source":"Crossref","is-referenced-by-count":24,"title":["Human papillomavirus testing for triage of women with low\u2010grade squamous intraepithelial lesions"],"prefix":"10.1002","volume":"132","author":[{"given":"Jack","family":"Cuzick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thomas Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Einstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Stoler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Trupin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0489-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00413-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.12.004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fe777f"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318192497c"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPZ5JY6FCVNMOT"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.024"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1742-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00623.x"},{"key":"e_1_2_5_13_2","unstructured":"NHS Cervical Screening Programme HPV triage and test of cure protocol. 2011. Available at:http:\/\/www.cancerscreening.nhs.uk\/cervical\/hpv\u2010triage\u2010test\u2010of\u2010cure.html. 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