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At a lower range (25 \u03bcM), RSV treatment for 48 hr causes arrest in the S\u2010phase of the cell cycle, while at a higher concentration range (50 \u03bcM), apoptosis can be detected, with activation of caspase\u20103. The histone\/protein deacetylase SIRT1 has been described as a putative target of RSV action in other model systems, even though its role in cancer cells is still controversial. Here we show that RSV, at both concentration ranges, leads to a marked increase in p53, while a decrease of SIRT1 expression level, as well as enzyme activity, only occurred at the higher concentration range. Concomitantly, however, treatments at both concentration ranges resulted in a marked increase in K373\u2010acetylated p53 and lysine\u2010acetylated FOXO3a. Immunohistochemical stainings of human lymph nodes show a preferential distribution of SIRT1 in the germinal center of the follicles while the mantle zone shows nearly no staining to few positive cells. The classical HL\u2010affected lymph nodes show a strong positivity of the diagnostic Hodgkin Reed\u2010Sternberg cells. Notably, both the HL\u2010derived cell lines and the Hodgkin Reed\u2010Sternberg cells of the affected lymph nodes derive from germinal center\u2010derived B cells. The study of SIRT1 distribution and expression on a larger number of biopsies might disclose a novel role for this histone\/protein deacetylase as therapeutic target.<\/jats:p>","DOI":"10.1002\/ijc.27748","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T05:59:34Z","timestamp":1343282374000},"page":"1013-1021","source":"Crossref","is-referenced-by-count":82,"title":["Resveratrol\u2010mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a 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