{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:32:18Z","timestamp":1777044738923,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In our study, we for the first time assessed the association of galectin\u20107 and S100A9 with clinicopathological variables and survival outcomes in cervical squamous carcinoma patients and explored the underlying molecular mechanisms in cervical squamous carcinoma cell lines. Immunohistochemical analysis of 243 patient samples showed that the positive staining rate for galectin\u20107 and S100A9 gradually decreased from normal cervical tissue to intraepithelial neoplasia and to cervical squamous carcinoma. Both galectin\u20107 and S100A9 showed significant negative association with lymph node metastasis and staging of cervical squamous carcinoma. Cervical squamous carcinoma patients with negative staining of galectin\u20107 or S100A9 showed significantly lower 5\u2010year overall survival rate than those with positive staining. Multivariate analysis with the Cox's proportional hazards model indicated that both galectin\u20107 and S100A9 had significant protective effect on cervical squamous carcinoma patients. Subsequent <jats:italic>in vitro<\/jats:italic> study in SiHa and C\u201033A human cervical squamous carcinoma cell lines revealed that knocking down galectin\u20107 or S100A9 enhanced tumor cell invasion and tumor cell viability against paclitaxel\u2010induced apoptotic stress, likely through increasing the matrix metalloproteinase\u20109 expression and activating the phosphatidylinositol 3\u2010kinase\/Akt signaling pathway, respectively. Knocking down both galectin\u20107 and S100A9 produced a synergistic effect, with galectin\u20107 displaying more significant and consistent protective effects than S100A9 on cervical squamous carcinoma cells. In summary, our study for the first time provides clinicopathological and <jats:italic>in vitro<\/jats:italic> evidence showing that both galectin\u20107 and S100A9 play important protective roles in cervical squamous carcinoma, which provides fresh insights into the biology of cervical squamous carcinoma.<\/jats:p>","DOI":"10.1002\/ijc.27764","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T18:42:18Z","timestamp":1344019338000},"page":"1051-1059","source":"Crossref","is-referenced-by-count":31,"title":["Roles of galectin\u20107 and S100A9 in cervical squamous carcinoma: Clinicopathological and <i>in vitro<\/i> evidence"],"prefix":"10.1002","volume":"132","author":[{"given":"Hong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Cong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Qiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Ping","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2008.0009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.067"},{"key":"e_1_2_6_4_2","unstructured":"Mayo Clinic staff. Cervical cancer. Available at:http:\/\/www.mayoclinic.com\/health\/cervical\u2010cancer\/DS00167(accessed Dec. 6 2011)"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-4-38"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.3781"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1385\/MO:23:1:113"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1527"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300762"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5458-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402870"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206631"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0985"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.08.028"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977781"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.10.013"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3638::AID-ELPS3638>3.0.CO;2-W"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02097.x"},{"key":"e_1_2_6_20_2","first-page":"27A","article-title":"The role of S100A9 in mediating the breast myoepithelial tumour\u2010suppressor effect","volume":"207","author":"Mulligan KT","year":"2005","journal-title":"J Pathol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900287a"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.07.009"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.31"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1239"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0134"},{"key":"e_1_2_6_26_2","first-page":"1373","article-title":"Induction of matrix metalloproteinase\u20109 by galectin\u20107 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma cells","volume":"22","author":"Park JE","year":"2009","journal-title":"Oncol Rep"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.083550"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0903435"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20090465"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.27764","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.27764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:35:40Z","timestamp":1697470540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.27764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,28]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/ijc.27764"],"URL":"https:\/\/doi.org\/10.1002\/ijc.27764","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,28]]}}}