{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:54:12Z","timestamp":1789444452914,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We studied marginal zone B\u2010cell lymphomas of the gastrointestinal tract including seven small cell lymphomas, eight large cell areas of composite lymphomas and 13 large cell variants using SNP array profiling. We found an increase of genomic complexity with lymphoma progression from small to large cytology, and identified gains of prominent (proto) oncogenes such as\n                    <jats:italic>REL<\/jats:italic>\n                    ,\n                    <jats:italic>BCL11A<\/jats:italic>\n                    ,\n                    <jats:italic>ETS1<\/jats:italic>\n                    ,\n                    <jats:italic>PTPN1<\/jats:italic>\n                    ,\n                    <jats:italic>PTEN<\/jats:italic>\n                    and\n                    <jats:italic>KRAS<\/jats:italic>\n                    which were found exclusively in the large cell variants. Copy numbers of\n                    <jats:italic>ADAM3A<\/jats:italic>\n                    ,\n                    <jats:italic>SCAPER<\/jats:italic>\n                    and\n                    <jats:italic>SIRPB1<\/jats:italic>\n                    were varying between the three different modes of presentation, hence suggestive for aberrations associated with progression from small to large cell lymphoma. The number of aberrations was slightly higher in the large cell part of composite lymphomas than in large cell lymphomas, suggesting that clonal selection takes place and that composite lymphomas are in a transition state. To further investigate this, we comparatively analyzed samples of two morphologically different regions of the same small cell tumor with a\n                    <jats:italic>BIRC3\u2010MALT1<\/jats:italic>\n                    translocation, as well as material acquired at two different time points from one composite lymphoma. We found genomic heterogeneity in both cases, supporting the theory of competing subclones in the evolution and progression of extranodal marginal zone B\u2010cell lymphoma.\n                  <\/jats:p>","DOI":"10.1002\/ijc.27774","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T03:27:21Z","timestamp":1344914841000},"source":"Crossref","is-referenced-by-count":26,"title":["High\u2010resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B\u2010cell lymphoma and its large cell 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