{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:43Z","timestamp":1790949883012,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the recent years, fluorine 18 fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) positron emission tomography (PET)\/computed tomography (CT) has emerged as a new modality for staging non\u2013small\u2010cell lung cancer (NSCLC) patients. The aim of this meta\u2010analysis was to assess the diagnostic value of <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT in detecting metastatic lesions in NSCLC patients. Meta\u2010analysis methods were used to pool sensitivity, specificity, positive and negative likehood ratios, diagnostic odd ratios and to construct a summary receiver\u2010operating characteristic curve. Data from included studies were pooled to compare the diagnostic accuracy between PET\/CT and PET or CT alone in nodal staging. Totally, 56 studies involving 8,699 patients met the inclusion criteria. The pooled sensitivities and specificities of <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT were 0.72 [95% confidence interval (CI): 0.65\u20130.78] and 0.91 (95% CI: 0.86\u20130.94) in determining mediastinal nodal staging; 0.71 (95% CI: 0.60\u20130.80) and 0.83 (95% CI: 0.77\u20130.88) in intrathoracic staging; 0.78 (95% CI: 0.64\u20130.87) and 0.90 (95% CI: 0.84\u20130.94) in intrathoracic staging on a per\u2010node basis. For detecting extrathoracic metastases, the pooled sensitivities and specificities of <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT were 0.77 (95% CI: 0.47\u20130.93) and 0.95 (95% CI: 0.92\u20130.97) for all extrathoracic metastases; 0.91 (95% CI: 0.80\u20130.97) and 0.98 (95% CI: 0.94\u20130.99) for bone metastases. <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT is beneficial in detecting lymph node metastases and extrathoracic metastases although PET\/CT showed low sensitivity in detecting brain metastases. <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT confers significantly higher sensitivity and specificity than contrast\u2010enhanced CT (both <jats:italic>p<\/jats:italic> &lt; 0.01) and higher sensitivity than <jats:sup>18<\/jats:sup>F\u2010FDG PET in staging NSCLC (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p>","DOI":"10.1002\/ijc.27779","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T07:27:10Z","timestamp":1344929230000},"source":"Crossref","is-referenced-by-count":101,"title":["Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography\/computed tomography for the detection of metastases in non\u2013small\u2010cell lung cancer patients"],"prefix":"10.1002","volume":"132","author":[{"given":"Yihua","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.311105039"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035536"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292021598"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.2081"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21106"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1362"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.142.6.1101"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00253-4"},{"key":"e_1_2_7_11_2","first-page":"1191","article-title":"Whole\u2010body positron emission tomography, part 1: methods and performance characteristics","volume":"33","author":"Dahlbom M","year":"1992","journal-title":"J Nucl Med"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.3.r99se21803"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-200605000-00004"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.01.075"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.067"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1710"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00134-003-1761-8","article-title":"A readers' guide to the interpretation of diagnostic test properties: clinical example of sepsis","volume":"29","author":"Fischer JE","year":"2003","journal-title":"Intens Care Med"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330081039"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7305.157"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-9"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.10.031"},{"key":"e_1_2_7_25_2","first-page":"50","article-title":"Brain metastasis in lung cancer. Comparison of cerebral MRI and 18F\u2010FDG\u2010PET\/CT for diagnosis in the initial staging","author":"Kruger S","year":"2011","journal-title":"Nuklearmedizin"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.6.1132"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-010-0064-6"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.57.305"},{"key":"e_1_2_7_29_2","first-page":"1749","article-title":"Accuracy of 18F\u2010FDG PET\/CT for lymph node staging in non\u2010small\u2010cell lung cancers","volume":"122","author":"Liu BJ","year":"2009","journal-title":"Chin Med J"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318220c912"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.1.67"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1155-4"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22518"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.12.047"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.220392"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.05.044"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.056408"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.072959"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2019"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318225914e"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256766"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1271148"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.2.275"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1181-2"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.12.004"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110281"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.07.039"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.037"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.03.074"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182173810"},{"key":"e_1_2_7_51_2","first-page":"287","article-title":"The validity of preoperative lymph node staging guidelines of European Society of Thoracic Surgeons in non\u2010small\u2010cell lung cancer patients","volume":"40","author":"Gunluoglu MZ","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_52_2","first-page":"506","article-title":"[Value of positron emission tomography\u2010computed tomography in the diagnosis of mediastinal lymph node metastasis of non\u2010small cell lung cancer]","volume":"30","author":"Li XD","year":"2010","journal-title":"Nan Fang yi ke da Xue Xue Bao [J Southern Med Univ]"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.154476"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3772"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1412-6"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2009.03.012"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.01.036"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.04.003"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.03.035"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21858"},{"key":"e_1_2_7_61_2","first-page":"925","article-title":"[Evaluation of the diagnostic value of 18F\u2010FDG PET\u2010CT and enhanced CT for staging of lymph node metastasis in non\u2010small cell lung cancer]","volume":"31","author":"Yang WF","year":"2009","journal-title":"Zhonghua Zhong Liu Za Zhi [Chin J Oncol]"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.01.031"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/0218492309349253"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2482071822"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2008.n.007"},{"key":"e_1_2_7_66_2","first-page":"306","article-title":"[Significance of dual\u2010time\u2010point 18F\u2010FDG PET imaging in evaluation of hilar and mediastinal lymph node metastasis in non\u2010small\u2010cell lung cancer]","volume":"30","author":"Hu M","year":"2008","journal-title":"Zhonghua Zhong Liu Za Zhi [Chin J Oncol]"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2008.9.6.481"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2006.150664"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.10.043"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0186-3"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0284-4"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2412051173"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00789.x"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)52634-2"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050327"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.27779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.27779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:52:50Z","timestamp":1697471570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.27779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,15]]}},"alternative-id":["10.1002\/ijc.27779"],"URL":"https:\/\/doi.org\/10.1002\/ijc.27779","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}