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The design was a randomised (1:1) health services study in Finland with intake between 2003 and 2007. We estimated sensitivity by the incidence method within one screening round. Overdiagnosis was based on the rate of cervical intraepithelial Grade 3 (CIN3) lesions diagnosed at screen and during the following interval. Out of 203,788 randomised women 132,298 attended (65% in both study arms) and 600,753 person\u2010years accumulated among attenders up to the end of 2010. In all attenders, 34 invasive cervical cancers and 288 CIN3 lesions were diagnosed at screen or during the following interval. The interval cancer incidence was 2.5\/10<jats:sup>5<\/jats:sup> person\u2010years (sensitivity 0.87) and 1.4 (sensitivity 0.93) in the HPV arm and Pap test arm, respectively. The rate of CIN3 lesions was 57.1 and 38.8, respectively. In conclusion, sensitivity of HPV testing was similar to that of Pap testing but caused more overdiagnosis. Therefore, implementation of HPV testing needs to be reconsidered especially in countries with well organised programmes.<\/jats:p>","DOI":"10.1002\/ijc.27850","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T10:45:07Z","timestamp":1347965107000},"page":"2141-2147","source":"Crossref","is-referenced-by-count":65,"title":["The HPV test has similar sensitivity but more overdiagnosis than the Pap test\u2014A randomised health services study on cervical cancer screening in Finland"],"prefix":"10.1002","volume":"132","author":[{"given":"Nea","family":"Malila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarit","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kotaniemi\u2010Talonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Laurila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Tarkkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Hakama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn065"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603210"},{"key":"e_1_2_7_5_2","volume-title":"Handbooks of cancer prevention cervix cancer screening","author":"IARC","year":"2005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603843"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1804"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1754"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70296-0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1258\/096914107782912077"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602799"},{"issue":"9","key":"e_1_2_7_16_2","first-page":"1","article-title":"Effect of screening for cancer in the Nordic countries on deaths, cost and quality of life up to the year 2017","volume":"36","author":"Hristova L","year":"1997","journal-title":"Acta Oncol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0569"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841860903386390"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00063-W"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b052de"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253239.87040.23"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098430"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.593547"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117485"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600974"},{"key":"e_1_2_7_26_2","volume-title":"Screening for cancer of the uterine cervix (IARC Scientific Publications No. 76)","author":"Hakama M","year":"1986"},{"key":"e_1_2_7_27_2","article-title":"Could HPV testing become the sole primary cervical screening test? 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