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Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER\u2010PR\u2010) (<jats:italic>n<\/jats:italic> = 990) and ER+PR+ (<jats:italic>n<\/jats:italic> = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER\u2010PR\u2010 and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08\u20131.20]) had a stronger risk association than leg length (1.05[1.00\u20131.11]). In comparison, for ER\u2010PR\u2010 disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (\u226413 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER\u2010PR\u2010 disease. Indicators of exposures during rapid growth periods were associated with risks of both HR\u2010defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR\u2010positive and \u2212negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women.<\/jats:p>","DOI":"10.1002\/ijc.27913","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T06:51:43Z","timestamp":1350975103000},"page":"2619-2629","source":"Crossref","is-referenced-by-count":71,"title":["Height, age at menarche and risk of hormone receptor\u2010positive and \u2010negative breast cancer: A cohort 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