{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:50:53Z","timestamp":1761519053976},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Genetically determined capacity for<jats:italic>NER<\/jats:italic>may modulate both cancer risk and prognosis. Thus, we evaluated associations of seven selected variants in the<jats:italic>NER<\/jats:italic>core genes with recurrence risk in 658 squamous cell carcinoma of the oropharynx (SCCOP) patients treated principally by radiation. The seven polymorphisms in the core<jats:italic>NER<\/jats:italic>genes (<jats:italic>XPC\u2010<\/jats:italic>rs2228000,<jats:italic>XPC\u2010<\/jats:italic>rs2228001,<jats:italic>XPD\u2010<\/jats:italic>rs1799793,<jats:italic>XPD\u2010<\/jats:italic>rs13181,<jats:italic>XPG\u2010rs<\/jats:italic>17655,<jats:italic>ERCC1\u2010<\/jats:italic>rs3212986 and<jats:italic>XPA\u2010<\/jats:italic>rs1800975<jats:italic>)<\/jats:italic>were genotyped using PCR\u2010RFLP method and log\u2010rank test and multivariable Cox models were used to evaluate the associations in both dominant and recessive genetic models. In a dominant model, we found that polymorphisms of<jats:italic>XPC\u2010<\/jats:italic>rs2228000,<jats:italic>XPD\u2010<\/jats:italic>rs1799793 and<jats:italic>XPG\u2010<\/jats:italic>rs17655 were significantly associated with disease\u2010free survival (log\u2010rank,<jats:italic>p<\/jats:italic>\u2009=\u20090.014;<jats:italic>p<\/jats:italic>\u2009=\u20090.00008;<jats:italic>p<\/jats:italic>\u2009=\u20090.0007, respectively), and these polymorphisms were significantly associated with recurrence risk of SCCOP (hazard ratio (HR)\u2009=\u20091.6, 95% confidence interval (CI) 1.1\u20132.3 for<jats:italic>XPC\u2010<\/jats:italic>rs2228000; HR\u2009=\u20090.4, 95% 0.3\u20130.6 for<jats:italic>XPD\u2010<\/jats:italic>rs1799793 and HR\u2009=\u20090.5, 95% CI 0.4\u20130.8 for<jats:italic>XPG\u2010<\/jats:italic>rs17655) after multivariable adjustment. Moreover, the borderline significant or significant associations were also found for these three polymorphisms in HPV16\/18\u2010positive SCCOP patients (HR\u2009=\u20091.6, 95% CI 1.0\u20134.1 for<jats:italic>XPC\u2010<\/jats:italic>rs2228000; HR\u2009=\u20090.2, 95% CI 0.1\u20130.5 for<jats:italic>XPD\u2010<\/jats:italic>rs1799793 and HR\u2009=\u20090.1, 95% CI 0.0\u20130.9 for<jats:italic>XPG\u2010<\/jats:italic>rs17655). However, similarly significant associations were not found for these polymorphisms in a recessive model. These findings suggest that polymorphisms of<jats:italic>XPC\u2010<\/jats:italic>rs2228000,<jats:italic>XPD\u2010<\/jats:italic>rs1799793 and<jats:italic>XPG\u2010<\/jats:italic>rs17655 in the<jats:italic>NER<\/jats:italic>core genes may contribute to recurrence risk of SCCOP, particularly HPV\u2010positive SCCOP, in a dominant but not in a recessive model. However, validation of these results is warranted.<\/jats:p>","DOI":"10.1002\/ijc.28051","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T09:57:45Z","timestamp":1358762265000},"page":"695-704","source":"Crossref","is-referenced-by-count":16,"title":["Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx"],"prefix":"10.1002","volume":"133","author":[{"given":"Xicheng","family":"Song","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Yuhuangding Hospital of Qingdao University Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston 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