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In this study, we performed clinicopathological and cell biological analyses of ICAM\u20101 expression in oral squamous cell carcinoma (SCC). First, we examined the ICAM\u20101 expression in tongue SCC immunohistochemically, and revealed that ICAM\u20101 was expressed predominantly at the invasive front area of tongue SCC. ICAM\u20101 expression at the invasive front area was correlated with invasion, lymph node metastasis and increased blood and lymphatic vessel density of the tongue SCC. The relationship between ICAM\u20101 expression and clinicopathological factors were consistent with the increased proliferation, invasion and cytokine\u2010production activities of ICAM\u20101\u2010transfected SCC cells. Second, we analyzed the relationship between macrophages and ICAM\u20101\u2010expressing tongue SCC cells because ICAM\u20101 is known to act as a ligand for adhesion of immune cells. Increased ICAM\u20101 expression in tongue SCC was correlated with increased macrophage infiltration within SCC nests. Moreover, macrophage\/SCC\u2010cell adhesion through ICAM\u20101 molecule was revealed using an <jats:italic>in vitro<\/jats:italic> cell adhesion and blockade assay. These findings indicate that ICAM\u20101 plays an important role in tongue SCC progression, which may result from the SCC\u2010cell activity, angiogenic activity, lymphangiogenic activity and macrophage\/SCC\u2010cell adhesion.<\/jats:p>","DOI":"10.1002\/ijc.28066","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T10:56:45Z","timestamp":1359543405000},"page":"568-578","source":"Crossref","is-referenced-by-count":90,"title":["Intercellular adhesion molecule\u20101 (ICAM\u20101) expression correlates with oral cancer progression and induces macrophage\/cancer cell adhesion"],"prefix":"10.1002","volume":"133","author":[{"given":"Yu","family":"Usami","sequence":"first","affiliation":[{"name":"Clinical Laboratory Osaka University Dental Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Osaka University Graduate School of 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