{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:25:12Z","timestamp":1787160312710,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T00:00:00Z","timestamp":1362787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:p>\n                    The effects of soy or isoflavone intake on breast cancer need to be examined further in epidemiologic studies. We assessed the associations of soy and isoflavone intake with breast cancer incidence in a population\u2010based prospective cohort study in Japan. Participants were members from the Takayama study, aged 35 years or older in 1992. The follow\u2010up was conducted from the time of the baseline study (September 1, 1992) to the end of March 2008. Cancer incidence was mainly confirmed through regional population\u2010based cancer registries. Breast cancer was defined as code C50 according to ICD\u201010. Soy and isoflavone intakes were assessed with a validated food frequency questionnaire. Using the Cox proportional hazard models, the association of soy and isoflavone intake with breast cancer was assessed after adjustments for age, body mass index, physical activity, smoking, alcohol consumption, education, age at menarche, age at first delivery, menopausal status, number of children and history of hormone replacement therapy. Among the 15,607 women analyzed, 172 had developed breast cancer. The relative risks of postmenopausal breast cancer were lower among women with higher intakes of soy (trend\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023) and isoflavone (trend\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046), although the relative risks of premenopausal breast cancer were not associated with intakes of soy and isoflavone. Decreased risks of breast cancer were found even among women with a moderate intake of soy and isoflavone. These results suggested that soy and isoflavone intakes have a protective effect on postmenopausal breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/ijc.28088","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T08:37:57Z","timestamp":1360139877000},"page":"952-960","source":"Crossref","is-referenced-by-count":90,"title":["Soy isoflavone intake and breast cancer risk in Japan: From the Takayama study"],"prefix":"10.1002","volume":"133","author":[{"given":"Keiko","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozue","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kumiai Kosei Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoharu","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kumiai Kosei Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Tanabashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Takayama Red Cross Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogen","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Radiology Takayama Red Cross Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tokimitsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Takayama Red Cross Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5501_1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02633520"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.210"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-208-43843"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.7.1451"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690584"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1270-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604145"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.52.428"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj102"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20090181"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.26736V"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021381101632"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.6.1437S"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9023-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.12.906"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690837"},{"key":"e_1_2_5_19_1","volume-title":"Life style and mortality. 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