{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:03:18Z","timestamp":1761292998849},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Traditionally, patients treated with chemoradiotherapy for node\u2010positive oropharyngeal squamous cell carcinoma (N<jats:sup>+<\/jats:sup> OPSCC) have undergone a planned neck dissection (ND) after treatment. Recently, negative post\u2010treatment positron\u2010emission tomography (PET)\/computed tomography (CT) imaging has been found to have a high negative predictive value for the presence of residual disease in the neck. Here, we present the first comprehensive analysis of a large, uniform cohort of N<jats:sup>+<\/jats:sup> OPSCC patients achieving a PET\/CT\u2010based complete response (CR) after chemoradiotherapy, and undergoing observation, rather than ND. From 2002 to 2009, 302 patients with N<jats:sup>+<\/jats:sup> OPSCC treated with 70 Gy intensity\u2010modulated radiation therapy and concurrent chemotherapy underwent post\u2010treatment clinical assessment including PET\/CT. CR was defined as no evidence of disease on clinical examination and post\u2010treatment PET\/CT. ND was reserved for patients with &lt;CR on either PET\/CT, clinical examination, or other imaging. 260 patients (86.1%) had clinical and radiographic CRs, and underwent neck observation (rate of regional control, 97.7%; 5\u2010year overall survival, 79.8%). The four observed patients experiencing neck recurrence had initial staging of N1 (<jats:italic>n<\/jats:italic>\u2009=\u20092), N2b (<jats:italic>n<\/jats:italic>\u2009=\u20091), and N2c (<jats:italic>n<\/jats:italic>\u2009=\u20091). Three of four were successfully surgically salvaged. There was no association between <jats:italic>N<\/jats:italic> stage and rate of neck recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.74). 52 and 25% of patients undergoing ND had viable tumor in the neck after positive and negative PET\/CT, respectively. We conclude that patients achieving CRs after chemoradiation, based on clinical and PET\/CT assessment, have a high probability of regional control, with a 2.3% regional failure rate, and may be safely observed without planned ND.<\/jats:p>","DOI":"10.1002\/ijc.28120","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T09:50:06Z","timestamp":1361526606000},"page":"1214-1221","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010term regional control in the observed neck following definitive chemoradiation for node\u2010positive oropharyngeal squamous cell cancer"],"prefix":"10.1002","volume":"133","author":[{"given":"Anuj","family":"Goenka","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc G.T.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Wolden","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis H.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Ohri","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Setton","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin H.","family":"Lok","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeem","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borys R.","family":"Mychalczak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Schoder","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Zelefsky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110504"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90031-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.11.2219"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.35"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90030-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<559::AID-HED1>3.0.CO;2-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.044792"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20130"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20629"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000257611.65290.aa"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.09.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.983"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21173"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.5.526"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.072"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1655-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.3300"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000215176.98582.A9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1136"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.066"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.050"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941001)74:7<1933::AID-CNCR2820740718>3.0.CO;2-X"},{"key":"e_1_2_10_25_1","first-page":"823","article-title":"The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial","volume":"10","author":"Khuri FR","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.3335"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2011.0055"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02603-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp405"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.4.401"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319890"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21021"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.28120","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.28120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:55:05Z","timestamp":1696352105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.28120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,29]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/ijc.28120"],"URL":"https:\/\/doi.org\/10.1002\/ijc.28120","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,29]]}}}