{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:40:54Z","timestamp":1768876854842,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Interactions of carcinogenic human papillomaviruses (most notably HPV types 16\/18\/31\/33\/45), and HPV6 or <jats:italic>Chlamydia trachomatis<\/jats:italic> are not well understood. We have used seroconversions to study effects the order of these infections has on the risk of high\u2010grade cervical precancer. In a cohort of 94,349 Finnish women with paired sera from consecutive pregnancies within an average of 2.4 years, 490 were diagnosed with cervical CIN3\/AIS. Serum antibodies to HPV6\/16\/18\/31\/33\/45 and <jats:italic>C. trachomatis<\/jats:italic> were measured in paired sera of the cases and a subcohort of 2,796 women with a minimum of two pregnancies. HPV16\u2010adjusted rate ratios (RR) and confidence intervals were estimated by stratified Cox model. Compared to dual seropositivity already at the first serum sampling, RRs related to HPV6 seropositivity before and after HPV31 seroconversion were 0.4 (95% CI 0.0, 4.4) and 10 (95% CI 1.8, 57). Furthermore, RR related to seroconversions of both HPV18\/45 and <jats:italic>C.trachomatis<\/jats:italic> between the consecutive pregnancies was 28 (95% CI 4.3, 190). Virtually concomitant HPV18\/45 and <jats:italic>C.trachomatis<\/jats:italic> infections are associated with very high CIN3 risk.<\/jats:p>","DOI":"10.1002\/ijc.28173","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T21:24:16Z","timestamp":1364073856000},"page":"1756-1759","source":"Crossref","is-referenced-by-count":19,"title":["Order of HPV\/<i>Chlamydia<\/i> infections and cervical high\u2010grade precancer risk: A case\u2010cohort study"],"prefix":"10.1002","volume":"133","author":[{"given":"Tapio","family":"Luostarinen","sequence":"first","affiliation":[{"name":"Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Proscovia B.","family":"Namujju","sequence":"additional","affiliation":[{"name":"Department of Children Young People and Families National Institute for Health and Welfare Oulu Finland"},{"name":"School of Health 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