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An unbiased subset of women in the atypical squamous cell of undetermined significance \/low\u2010grade squamous intraepithelial lesion Triage Study provided blood samples at trial enrollment for serological testing. A Luminex assay based on glutathione s\u2010transferase\u2010L1 fusion proteins as antigens was used to test seroreactivity against eight carcinogenic HPV genotypes (16, 18, 31, 33, 35, 45, 52 and 58). We analyzed the relationship between seroprevalence in women free of precancer (<jats:italic>N<\/jats:italic> = 2,464) and HPV DNA status, age, sexual behavior and other HPV\u2010related risk factors. The overall seroprevalence was 24.5% for HPV16 L1 and \u223c20% for 18L1 and 31L1. Among women free of precancer, seroprevalence peaked in women less than 29 years and decreased with age. Type\u2010specific seroprevalence was associated with baseline DNA detection for HPV16 (OR = 1.36, 95%CI: 1.04\u20131.79) and HPV18 (OR = 2.31, 95%CI: 1.61\u20133.32), as well as for HPV52 and HPV58. Correlates of sexual exposure were associated with increased seroprevalence across most genotypes. Women who were current or former smokers were less likely to be seropositive for all eight of the tested oncogenic genotypes. The multiplex assay showed associations between seroprevalence and known risk factors for HPV infection across nearly all tested HPV genotypes but associations between DNA\u2010 and serostatus were weak, suggesting possible misclassification of the participants' HPV serostatus.<\/jats:p>","DOI":"10.1002\/ijc.28215","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T18:05:57Z","timestamp":1366049157000},"page":"2172-2181","source":"Crossref","is-referenced-by-count":16,"title":["Natural immune responses against eight oncogenic human papillomaviruses in the ASCUS\u2010LSIL Triage Study"],"prefix":"10.1002","volume":"133","author":[{"given":"Lauren E.","family":"Wilson","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health  Bethesda, 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