{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:07:48Z","timestamp":1790215668768,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Anal squamous cell carcinomas are predominantly associated with high\u2010risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of \u201clow\u2010risk\u201d HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV\u2010related anogenital cancers, the overall distribution of these genotypes in the anal canal and perianal tissue may differ to that in the cervix. In addition, although the majority of anal and perianal cancers are associated with HPV, some are not; hence, confirmation of direct association of the virus within a lesion is important. Using laser capture microdissection, anal and perianal invasive carcinomas and high\u2010grade squamous intraepithelial lesions (HSILs) in biopsies previously associated with HPV 6 or 11 alone were isolated from tissue sections and HPV genotype tested. Of seven cases tested, four invasive carcinomas were positive for HPV 6 only, one invasive carcinoma was negative for HPV and two HSILs were positive for HPV 11 only. All samples were confirmed as HPV 16\/18 negative using two different DNA targets (E6 and L1). From these results, we confirm that HPV 6 and 11 can occasionally be associated with high\u2010grade lesion and anal cancer.<\/jats:p>","DOI":"10.1002\/ijc.28228","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T23:28:39Z","timestamp":1366846119000},"page":"2253-2258","source":"Crossref","is-referenced-by-count":89,"title":["Anal and perianal squamous carcinomas and high\u2010grade intraepithelial lesions exclusively associated with \u201clow\u2010risk\u201d HPV genotypes 6 and 11"],"prefix":"10.1002","volume":"133","author":[{"given":"Alyssa M.","family":"Cornall","sequence":"first","affiliation":[{"name":"Regional HPV Labnet Reference Laboratory, Department of Microbiology and Infectious Diseases The Royal Women's Hospital Parkville VIC Australia"},{"name":"Murdoch Children's Research Institute Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer 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