{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:45:03Z","timestamp":1791092703004,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:p>To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of \u03b1v\u03b23, \u03b1v\u03b25, \u03b1v\u03b26 and \u03b1v\u03b28 integrins in primary malignancies and metastases to brain of breast, lung and renal carcinomas and in malignant melanoma. Inhibitors of \u03b1v integrins are currently in clinical trials for glioblastoma. The role of integrins in the process of brain metastasis from other human tumors is unknown. Immunohistochemistry with novel integrin subtype specific rabbit monoclonal antibodies was performed on tissue microarrays of archival material of surgical biopsies taken from primary tumors and brain metastases. Integrin \u03b1v\u03b23 expression was increased in brain metastases compared to primary tumors of breast adenocarcinoma, non\u2010small cell lung cancer, renal clear cell cancer and malignant cutaneous melanoma (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Similarly, integrin \u03b1v\u03b28 expression was increased in brain metastases compared to primary tumors of breast cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), lung cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and renal cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), with a similar trend in metastatic melanoma. Integrin \u03b1v\u03b25 was expressed in most primary tumors (98% breast cancer; 67% lung cancer; 90% renal cancer; 89% melanoma) and showed a stronger expression in brain metastases compared to primary tumors from lung cancer and melanoma (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Also integrin \u03b1v\u03b26 expression was increased in brain metastases compared to primary breast cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Conclusions: The stronger \u03b1v\u2010integrin expression in brain metastases, especially of \u03b1v\u03b23 and \u03b1v\u03b28 integrins, suggests that certain \u03b1v integrin are involved in the process of brain metastasis. \u03b1v Integrins may be therapeutic targets for patients with metastatic cancer in brain.<\/jats:p>","DOI":"10.1002\/ijc.28267","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T07:14:26Z","timestamp":1368170066000},"page":"2362-2371","source":"Crossref","is-referenced-by-count":102,"title":["\u03b1v\u2010Integrin isoform expression in primary human tumors and brain metastases"],"prefix":"10.1002","volume":"133","author":[{"given":"Alexander","family":"Vogetseder","sequence":"first","affiliation":[{"name":"Department of Pathology Institute for Surgical Pathology, University Hospital Zurich  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