{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:14:08Z","timestamp":1777457648065,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro\u2010inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls from the European Prospective Investigation into Cancer cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log\u2010additive model, we found a significant association between SNPs in <jats:italic>CD14<\/jats:italic>, <jats:italic>NOD2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic> with GC risk. However, after applying the multiple comparisons tests only the <jats:italic>NOD2<\/jats:italic> region remained significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). Analysis according to anatomical subtypes revealed <jats:italic>NOD2<\/jats:italic> and <jats:italic>NFKB1<\/jats:italic> SNPs associated with noncardia GC and <jats:italic>CD14<\/jats:italic> SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of <jats:italic>NOD2<\/jats:italic> with noncardia GC (<jats:italic>p<\/jats:italic>\u2009=\u20090.0003) and <jats:italic>CD14<\/jats:italic> with cardia GC (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Haplotype analysis was in agreement with single SNP results for <jats:italic>NOD2<\/jats:italic> and <jats:italic>CD14<\/jats:italic> genes. From these results, we conclude that genetic variation in <jats:italic>NOD2<\/jats:italic> associates with noncardia GC while variation in <jats:italic>CD14<\/jats:italic> is associated with cardia GC.<\/jats:p>","DOI":"10.1002\/ijc.28357","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T23:26:20Z","timestamp":1372893980000},"page":"92-101","source":"Crossref","is-referenced-by-count":33,"title":["Polymorphisms of <i>Helicobacter pylori<\/i> signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer\u2010eurgast cohort"],"prefix":"10.1002","volume":"134","author":[{"given":"Osmel","family":"Companioni","sequence":"first","affiliation":[{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology\u2010IDIBELL Barcelona 08908 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Bonet","sequence":"additional","affiliation":[{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology\u2010IDIBELL Barcelona 08908 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology\u2010IDIBELL Barcelona 08908 Spain"},{"name":"Molecular Epidemiology Group Translational Research Laboratory Catalan Institute of Oncology\u2013IDIBELL Barcelona 08908 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Faculty of Health Sciences University of Troms\u00f8 Troms\u00f8 Norway"},{"name":"Department of Research Cancer Registry of Norway Oslo Norway"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Samfundet Folkh\u00e4lsan Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Panico","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Federico II University Naples  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[{"name":"Cancer Registry and Histopathology Unit \u201cCivile \u2010 M.P. 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