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All patients in The Netherlands Cancer Registry diagnosed with invasive primary squamous cell carcinoma of the larynx during the period 1989\u20132010 were included for analysis. Time trends in incidence, mortality, treatment and survival were described for the total group and stratified by sex and subsite: glottis, supraglottis and subglottis. The most frequently affected subsite for men was the glottis (69%) and for women the supraglottis (55%). Glottic cancer was diagnosed at lower stages than supraglottic cancer. Incidence and mortality rates decreased for males with \u22122.5 and \u22122.8% per year, respectively, but remained stable for women, except for an increasing mortality rate in older women (EAPC: +2.5%). Five\u2010year relative survival rates were stable for glottic (85%) and supraglottic (50%) cancer, whereas patients with high\u2010staged cancers more often received radiotherapy. Multivariable analysis showed lower relative excess risks of dying for women, younger patients (&lt;75 years), glottic cancer, lower stage cancer and those undergoing surgery. Changes in incidence and mortality rates are in line with changing smoking habits in The Netherlands. Declining incidence with stable survival rates gives rise to hope and worry at the same time.<\/jats:p>","DOI":"10.1002\/ijc.28388","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T10:55:10Z","timestamp":1374231310000},"page":"674-681","source":"Crossref","is-referenced-by-count":39,"title":["Progress against laryngeal cancer in The Netherlands between 1989 and 2010"],"prefix":"10.1002","volume":"134","author":[{"given":"Boukje A.C.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Research Comprehensive Cancer Centre The Netherlands Utrecht The Netherlands"},{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrike E.","family":"Karim\u2010Kos","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem","family":"Coebergh","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Research Comprehensive Cancer Center South Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri A.M.","family":"Marres","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Nederlandse Kankerregistratie.Cijfers over kanker in Nederland.2012. 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