{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:52Z","timestamp":1788869632947,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The German HNPCC Consortium: Deutsche Krebshilfe","award":["German Cancer Aid 108252"],"award-info":[{"award-number":["German Cancer Aid 108252"]}]},{"name":"Central Manchester University Hospitals NHS Foundation Trust: Manchester BRC"},{"name":"St Marks Hospital Cancer Research UK Family Cancer Clinic: Cancer Research UK Imperial Cancer Centre","award":["CR-UK C37990\/A12196"],"award-info":[{"award-number":["CR-UK C37990\/A12196"]}]},{"DOI":"10.13039\/100009148","name":"Queen Mary University of London","doi-asserted-by":"crossref","award":["CR-UK grant number C8162\/A10406"],"award-info":[{"award-number":["CR-UK grant number C8162\/A10406"]}],"id":[{"id":"10.13039\/100009148","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatch repair deficiency was excluded by genetic testing. Families were classified as FCC type X if they fulfilled the original Amsterdam criteria (AC) and late onset (LOFCC) if they fulfilled the AC apart from not having a cancer aged under 50. The most advanced findings on colonoscopy were analyzed. One thousand five hundred eighty\u2010five individuals (median age 47.3, 44% male) from 530 FCC families (349 FCC type X) underwent a total of 4,992 colonoscopies with 7,904 patient\u2010years of follow\u2010up. Results for FCC type X and LOFCC were very similar. At baseline, 22 prevalent asymptomatic colorectal cancers were diagnosed, 120 (7.6%) individuals had high\u2010risk adenomas and 225 (14.2%) simple adenomas. One thousand eighty\u2010eight individuals had a further colonoscopy (median follow\u2010up of 6.2 years). Of nine individuals diagnosed with cancer, eight had a previous history of at least one polyp\/adenoma. High\u2010risk adenomas were detected in 92 (8.7%) and multiple adenomas were detected in 20 (1.9%) individuals. Both FCC type X and LOFCC have a high prevalence of colorectal cancers and on follow\u2010up develop high\u2010risk adenomas (including multiple adenomas), but infrequent interval cancers. They should be managed similarly with five\u2010yearly colonoscopies undertaken from between 30 and 40 with more intensive surveillance in individuals developing multiple or high\u2010risk adenomas.<\/jats:p>","DOI":"10.1002\/ijc.28397","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T12:27:21Z","timestamp":1375187241000},"page":"939-947","source":"Crossref","is-referenced-by-count":22,"title":["A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer"],"prefix":"10.1002","volume":"134","author":[{"given":"David","family":"Mesher","sequence":"first","affiliation":[{"name":"Queen Mary University of London Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis","family":"Dove\u2010Edwin","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Imperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sasieni","sequence":"additional","affiliation":[{"name":"Queen Mary University of London Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Vasen","sequence":"additional","affiliation":[{"name":"The Netherlands Foundation for the Detection of Hereditary Tumours Leiden The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Bernstein","sequence":"additional","affiliation":[{"name":"The Danish HNPCC\u2010register, Department of Gastroenterology and Clinical Research Center Copenhagen University Hospital Hvidovre Denmark"},{"name":"The Surgical Gastroenterology Department Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Royer\u2010Pokora","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics and Anthropology Heinrich Heine University, Medical Faculty Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Holinski\u2010Feder","sequence":"additional","affiliation":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen Campus Innenstadt, Medizinische Klinik und Poliklinik IV Ziemssenstr. 1 80336 Munich Germany"},{"name":"MGZ \u2013 Medizinisch Genetisches Zentrum Bayerstr. 3\u20105 80335 Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Lalloo","sequence":"additional","affiliation":[{"name":"Genetic Medicine Manchester Academic Health Science Centre, St Mary's Hospital Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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