{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:17:28Z","timestamp":1760242648535},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>P16\u2010INK4A overexpression has been proposed as a prognostic marker to manage the follow up of women with positive cytology and\/or HPV test but without high\u2010grade cervical intraepithelial neoplasia (CIN2+). This study measures the relative risk (RR) of CIN2+ of p16 positive versus negative in these women. All the women referred to colposcopy from October 2008 to September 2010 with negative or CIN1 colposcopy\u2010guided biopsy were included in the study; women surgically treated or having a CIN2\u20133 were excluded. All baseline biopsies were dyed with hematoxylin and eosin and p16. Women were followed up according to screening protocols, with cytology or colposcopy at 6 or 12 months. CIN2\/3 RRs and 95% confidence intervals (95%CI) were computed. Of 442 eligible women, 369 (83.5%) had at least one follow\u2010up episode. At baseline, 113 (30.6%) were CIN1, 248 (67.2%) negative, and 8 (2.2%) inadequate histology; 293 (79.4%) were p16\u2010negative, 64 (17.3%) p16 positive and 12 (3.2%) not valid. During follow up, we found ten CIN2 and three CIN3; of these, six were p16 positive (sensitivity 46%, 95% CI 19\u201375). The absolute risk among p16 positives was 9.4\/100 compared to 1.7\/100 of the p16 negatives (RR 5.5; 95% CI 1.7\u201317.4). The risk was also higher for CIN1 than for histologically negative women (RR 4.4; 95% CI 1.3\u201314.3). The RR for p16 in CIN1 did not change (RR 5.2; 95% CI 0.6\u201347.5). P16 overexpression is a good candidate for modulating follow\u2010up intensity after a negative colposcopy but is limited by its low prospective sensitivity.<\/jats:p>","DOI":"10.1002\/ijc.28407","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T04:20:24Z","timestamp":1375417224000},"page":"897-904","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic value of p16\u2010INK4A protein in women with negative or CIN1 histology result: A follow\u2010up study"],"prefix":"10.1002","volume":"134","author":[{"given":"Alberto","family":"Pacchiarotti","sequence":"first","affiliation":[{"name":"Lega Italiana per la Lotta ai Tumori Provincial Section of Latina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ferrari","sequence":"additional","affiliation":[{"name":"AUSL Reggio Emilia Epidemiology Unit Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bellardini","sequence":"additional","affiliation":[{"name":"Screening Unit Local Health Unit of Latina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Chini","sequence":"additional","affiliation":[{"name":"Laziosanit\u00e0 Public health agency Lazio Region Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Collina","sequence":"additional","affiliation":[{"name":"AUSL di Bologna UO Anatomia Patologica Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Dalla Palma","sequence":"additional","affiliation":[{"name":"Pathology Unit S. 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Anna Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Maccallini","sequence":"additional","affiliation":[{"name":"L'Aquila Screening Unit Pescina (AQ)  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Musolino","sequence":"additional","affiliation":[{"name":"Lega Italiana per la Lotta ai Tumori Provincial Section of Latina  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Pathology Central Hospital Bolzano Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pisa","sequence":"additional","affiliation":[{"name":"Anatomy Pathology Service Azienda Ospedaliera S. 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