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The oropharyngeal epithelium differs from the mucosal epithelium at other commonly HPV16\u2010infected sites (<jats:italic>i.e<\/jats:italic>., cervix and anogenital region) in that it is juxtaposed with the underlying lymphatic tissue, serving a key immunologic function in the surveillance of inhaled and ingested pathogens. Therefore, the natural history of infection and immune response to HPV at this site may differ from that at other anatomic locations. This review summarizes the literature concerning the adaptive immune response against HPV in the context of HNSCC, with a focus on the T\u2010cell response. Recent studies have shown that a broad repertoire of tumor\u2010infiltrating HPV\u2010specific T\u2010cells are found in nearly all patients with HPV\u2010positive tumors. A systemic response is found in only a proportion of these. Furthermore, the local response is more frequent in OPSCC patients than in cervical cancer patients and HPV\u2010negative OPSCC patients. Despite this, tumor persistence may be facilitated by abnormalities in antigen processing, a skewed T\u2010helper cell response, and an increased local prevalence of T\u2010regulatory cells. Nonetheless, the immunologic profile of HPV\u2010positive <jats:italic>vs<\/jats:italic>. HPV\u2010negative HNSCC is associated with a significantly better outcome, and the HPV\u2010specific immune response is suggested to play a role in the significantly better response to therapy of HPV\u2010positive patients. Immunoprofiling may prove a valuable prognostic tool, and immunotherapy trials targeting HPV are underway, providing hope for decreasing treatment\u2010related toxicity.<\/jats:p>","DOI":"10.1002\/ijc.28411","type":"journal-article","created":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T06:52:06Z","timestamp":1375512726000},"page":"2755-2763","source":"Crossref","is-referenced-by-count":104,"title":["The interplay between HPV and host immunity in head and neck squamous cell carcinoma"],"prefix":"10.1002","volume":"134","author":[{"given":"Anne Skou","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sophie","family":"Koldj\u00e6r S\u00f8lling","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aarhus University Hospital Aarhus 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