{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:05:31Z","timestamp":1790845531813,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,3,15]]},"abstract":"<jats:p>In sub\u2010Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross\u2010sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtained from women aged \u226521 years with lesions clinically suggestive of ICC. Histopathological diagnosis of ICC was determined by light microscopy examination of hematoxylin and eosin stained sections of paraffin\u2010embedded cervical specimens; samples with a confirmed histopathological diagnosis underwent HPV DNA testing by polymerase chain reaction. HPV\u2010positive specimens were typed by reverse hybridization line probe assay. Between October 2007 and March 2010, cervical specimens from 659 women were collected (167 in Ghana, 192 in Nigeria and 300 in South Africa); 570 cases were histologically confirmed as ICC. The tumor type was identified in 551\/570 women with ICC; squamous cell carcinoma was observed in 476\/570 (83.5%) cases. The HPV\u2010positivity rate in ICC cases was 90.4% (515\/570). In ICC cases with single HPV infection (447\/515 [86.8%]), the most commonly detected HPV types were HPV16 (51.2%), HPV18 (17.2%), HPV35 (8.7%), HPV45 (7.4%), HPV33 (4.0%) and HPV52 (2.2%). The prevalence of single and multiple HPV infections seemed higher among HIV\u2010positive women and HPV type distribution appeared to differ according to tumor type and HIV status. In conclusion, HPV16, 18, 45 and 35 were the most common HPV types in sub\u2010Saharan African women with ICC and HPV infections were more common in HIV\u2010positive women.<\/jats:p>","DOI":"10.1002\/ijc.28425","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T09:22:41Z","timestamp":1376040161000},"page":"1389-1398","source":"Crossref","is-referenced-by-count":157,"title":["Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub\u2010Saharan Africa"],"prefix":"10.1002","volume":"134","author":[{"given":"Lynette","family":"Denny","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Cape Town\/Groote Schuur Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Adewole","sequence":"additional","affiliation":[{"name":"Vice Chancellor College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Anorlu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology College of Medicine University of Lagos\/Lagos University Teaching Hospital Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Pretoria Academic Hospital Complex University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manivasan","family":"Moodley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Inkosi Albert Luthuni Central Hospital Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Charlotte Maxeke Johannesburg Academic Hospital University of Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Snyman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Pretoria Academic Hospital Complex University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Wiredu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ghana School of Allied Health Sciences Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anco","family":"Molijn","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory Rijswijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Quint","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory Rijswijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunasekaran","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals Ltd. 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