{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:17:08Z","timestamp":1760955428713},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T00:00:00Z","timestamp":1380931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,3,15]]},"abstract":"<jats:p>The insulin\u2010like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF\u2010I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross\u2010sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF\u2010I, IGFBP\u20103, the IGF\u2010I\/IGFBP\u20103 ratio, five common SNPs in the <jats:italic>IGF\u20101, IGFBP\u20103 and IGF\u20101R<\/jats:italic> genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD\u2009=\u20093.7) years, and average body mass index (BMI) at recruitment was 28.5 kg\/m<jats:sup>2<\/jats:sup>. Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm<jats:sup>2<\/jats:sup>. Mean IGF\u2010I and IGFBP\u20103 concentrations were 15.33 (SD: 5.52) nmol\/l and 114.96 (SD: 21.34) nmol\/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF\u2010I and IGF\u2010I\/IGFBP\u20103 concentrations had lower absolute dense (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.03 and 0.09, respectively) and nondense tissue areas (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women.<\/jats:p>","DOI":"10.1002\/ijc.28469","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T14:57:11Z","timestamp":1378393031000},"page":"1436-1444","source":"Crossref","is-referenced-by-count":15,"title":["Circulating concentrations of insulin\u2010like growth factor\u2010I, insulin\u2010like growth factor\u2010binding protein\u20103, genetic polymorphisms and mammographic density in premenopausal Mexican women: Results from the ESMaestras cohort"],"prefix":"10.1002","volume":"134","author":[{"given":"S.","family":"Rinaldi","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer (IARC) Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Biessy","sequence":"additional","affiliation":[{"name":"International Agency for 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