{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:18:14Z","timestamp":1768515494889,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Caloric restriction in animals is an effective way to reduce carcinogenesis. Anorexia nervosa (AN) is considered a model of extreme caloric restriction in humans. The aim of our study was to assess cancer incidence and mortality in women with AN. A total of 6,009 women with at least one inpatient treatment for AN during the period 1973\u20132003 were included in the study. Standardized incidence ratios (SIR) and standardized mortality ratios (SMR) were calculated. Overall, there was no statistically significant difference in cancer incidence compared to women in the general population. At a statistically significant or borderline significant level, a higher incidence for lung cancer and cancer of lymphoid, hematopoietic and related tissue was observed along with a reduced breast cancer incidence. Women with AN had twice as high mortality from cancer in general, and more specifically from melanoma, cancers of genital organs and cancers of ill\u2010defined, secondary and unspecified sites. The increased lung cancer incidence may be due to smoking habits among women with AN. The worse prognosis with higher mortality from melanoma, cancers of genital organs and cancers of ill\u2010defined, secondary and unspecified sites may be explained by AN\u2010specific attitudes toward seeking medical care, adherence to treatment or worse biological precondition due to starvation and cachexia.<\/jats:p>","DOI":"10.1002\/ijc.28495","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:47:48Z","timestamp":1381542468000},"page":"1751-1757","source":"Crossref","is-referenced-by-count":26,"title":["Cancer incidence and mortality patterns in women with anorexia nervosa"],"prefix":"10.1002","volume":"134","author":[{"given":"Georgios","family":"Karamanis","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Psychiatry Uppsala University, Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkistis","family":"Skalkidou","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tsakonas","sequence":"additional","affiliation":[{"name":"Department of Oncology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Brandt","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, Department of Medicine Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ekbom","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, Department of Medicine Karolinska University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Ekselius","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychiatry Uppsala University, Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotios C.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychiatry Uppsala University, Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i31.4199"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603932"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603703"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0100-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0675"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22968"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22762"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/87.3.245"},{"key":"e_1_2_5_12_1","first-page":"1095","article-title":"Lasting influence of early caloric restriction on prevalence of neoplasms in the rat","volume":"47","author":"Ross MH","year":"1971","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.11.2205"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6494"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173635"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11432"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051882"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008821524297"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh087"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008974414116"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.10.1226"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32831bc558"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.054742"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0718"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","unstructured":"Anzengruber D Klump KL Thornton L et al. 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