{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:03:46Z","timestamp":1791223426194,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"crossref","award":["R-2011-785-036"],"award-info":[{"award-number":["R-2011-785-036"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Patronato de Hospital Infantil de Mexico"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Mycosis fungoides (MF) is the most common variant of primary cutaneous T\u2010cell lymphoma, and decreased forkhead box P3 (FoxP3) expression has been reported in MF late stages. Hypoxia\u2010inducible factor 1 alpha (HIF\u20101\u03b1) may regulate FoxP3 expression; however, it is unknown whether HIF\u20101\u03b1 is expressed in the CD4<jats:sup>+<\/jats:sup> T cells of MF patients and how it could affect the expression of FoxP3. Therefore, we evaluated the expression of HIF\u20101\u03b1 and FoxP3 in CD4<jats:sup>+<\/jats:sup> T cells obtained from the skin lesions of MF patients. We found increased cell proliferation and an increase in CD4<jats:sup>+<\/jats:sup> T cells with an aberrant phenotype among early stage MF patients. HIF\u20101\u03b1 was overexpressed in these CD4<jats:sup>+<\/jats:sup> T cells. In addition, we found a decrease in the percentage of FoxP3<jats:sup>+<\/jats:sup> cells both in the skin of MF patients, when compared with control skin samples, and with disease progression. In addition, a negative correlation was established between HIF\u20101\u03b1 and FoxP3 expression. Skin HIF\u20101\u03b1 expression in MF patients correlated with the extent of the affected area and increased with the disease progression. Finally, we showed that <jats:italic>ex vivo<\/jats:italic> inhibition of HIF\u20101\u03b1 degradation increases the percentage of FoxP3<jats:sup>+<\/jats:sup> T cells in skin lesions. Our results suggest that overexpression of HIF\u20101\u03b1 affects the levels of FoxP3 in MF patients, which could have relevant implications in terms of disease outcome.<\/jats:p>","DOI":"10.1002\/ijc.28546","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:36:33Z","timestamp":1381750593000},"page":"2136-2145","source":"Crossref","is-referenced-by-count":17,"title":["Overexpression of hypoxia\u2010inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides\u2014Cutaneous T\u2010cell lymphoma: Clinical implications"],"prefix":"10.1002","volume":"134","author":[{"given":"M.","family":"Alc\u00e1ntara\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica Hospital de Especialidades Instituto Mexicano del Seguro Social M\u00e9xico city, M\u00e9xico"},{"name":"Departamento de Inmunolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto, Polit\u00e9cnico 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