{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:33:03Z","timestamp":1790400783533,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zentrales Innovationsprogramm Mittelstand (ZIM)","award":["KF2509802SK0"],"award-info":[{"award-number":["KF2509802SK0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic>\u2010specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six <jats:italic>H. pylori<\/jats:italic>\u2010specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow\u2010up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 <jats:italic>H. pylori<\/jats:italic>\u2010positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of <jats:italic>H. pylori<\/jats:italic> recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, <jats:italic>p<\/jats:italic> &lt; 0.0001) or intestinal metaplasia (IM, <jats:italic>p<\/jats:italic> = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42\u20134.55) for IM and 2.38 (95% CI = 1.05\u20135.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27\u20136.59) and 2.20 (95% CI = 1.33\u20133.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (<jats:italic>p<\/jats:italic><jats:sub>for trend<\/jats:sub> = 0.0003). This population\u2010based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high\u2010risk <jats:italic>H. pylori<\/jats:italic> strains, which are related to the development of GC in a Chinese high\u2010risk population, and recomLine test might serve as a tool for risk stratification.<\/jats:p>","DOI":"10.1002\/ijc.28560","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T03:36:43Z","timestamp":1382585803000},"page":"2118-2125","source":"Crossref","is-referenced-by-count":44,"title":["<i>Helicobacter pylori<\/i> antibody responses and evolution of precancerous gastric lesions in a Chinese population"],"prefix":"10.1002","volume":"134","author":[{"given":"Kai\u2010Feng","family":"Pan","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Formichella","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology Immunology and Hygiene Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute Beijing 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