{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T03:35:03Z","timestamp":1776569703908,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:p>Because of the differences in bacterial epitopes and host characteristics, infections with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) induce different immune responses. We explored the possibility that certain antibody response patterns are more closely linked to gastric adenocarcinoma (GAC) than others. In a Swedish population\u2010based case\u2010control study, serum samples were obtained from 268 cases and 222 controls, aged 40\u201379 years and frequency\u2010matched according to age and sex. We measured antibodies against 17 <jats:italic>H. pylori<\/jats:italic> proteins using multiplex serology. Associations were estimated with multivariably adjusted logistic regression models, using odds ratio (OR) with 95% confidence interval (CI) as measures of relative risk. Associations were essentially confined to non\u2010cardia GAC but did not differ significantly between intestinal and diffuse subtypes. Point estimates for all antibodies were above unity, 15 significant with top three being CagA (OR\u2009=\u20099.2), GroEL (6.6), HyuA (3.6). ORs were substantially attenuated in individuals with chronic atrophic gastritis. Principal component analysis identified two significant factors: a CagA\u2010dominant factor (antibodies against CagA, VacA and Omp as prominent markers), and a non\u2010CagA factor (antibodies against NapA and Catalase as prominent markers). Both factors showed dose\u2010dependent associations with non\u2010cardia GAC risk (CagA\u2010dominant factor, highest <jats:italic>vs<\/jats:italic>. lowest quartiles, OR\u2009=\u200916.2 [95% CI 4.8\u201354.9]; non\u2010CagA factor OR\u2009=\u20095.3 [95% CI 2.1\u201313.3]). Overall, our results confirm that serum antibodies against different <jats:italic>H. pylori<\/jats:italic> proteins are associated with the presence of non\u2010cardia GAC. Although strongest association is detected by antibodies against CagA and covarying proteins, a pattern of antibodies unrelated to CagA is also significantly linked to the risk of non\u2010cardia GAC.<\/jats:p>","DOI":"10.1002\/ijc.28621","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T05:06:48Z","timestamp":1385010408000},"page":"2942-2950","source":"Crossref","is-referenced-by-count":49,"title":["A CagA\u2010independent cluster of antigens related to the risk of noncardia gastric cancer: Associations between <i>Helicobacter pylori<\/i> antibodies and gastric adenocarcinoma explored by multiplex serology"],"prefix":"10.1002","volume":"134","author":[{"given":"Huan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm 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