{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:43:46Z","timestamp":1781826226914,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Since cervical cancer remains common in Mexico despite an established cytology screening program, the Ministry of Health recently introduced pilot front\u2010line HPV testing into the Mexican cervical cancer screening program (CCSP). Here, we present the key field performance metrics of this population\u2010based study. High\u2010risk HPV DNA (hrHPV) testing was conducted on self\u2010collected vaginal specimens from 100,242 women aged 25\u201375 years residing in Morelos State. All hrHPV positive women and a random sample of 3.2% (<jats:italic>n<\/jats:italic>\u2009=\u20092,864) of hrHPV negative participants were referred for colposcopic examination. The main disease endpoint of interest was cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We calculated relative risk, positive predictive value and negative predictive value adjusted for screening test verification bias. The overall prevalence of hrHPV was 10.8% (95%CI 10.6\u201311.0). Women positive for hrHPV had a relative risk of 15.7 for histologically detectable CIN2+. The adjusted positive predictive value of the hrHPV test was 2.4% (95%CI 2.1\u20132.7); whereas the adjusted negative predictive value was 99.8% (95%CI 99.8\u201399.9). These findings suggest that large\u2010scale vaginal hrHPV testing in a middle\u2010income country can identify women at greater risk of advanced cervical abnormalities in a programmatically meaningful way but care is warranted to ensure that disease not detectable at colposcopy is kept to a minimum. PASS shows areas that need improvement and sets the stage for wider use of hrHPV screening of self\u2010collected vaginal specimens in Mexico.<\/jats:p>","DOI":"10.1002\/ijc.28639","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T07:51:27Z","timestamp":1385625087000},"page":"109-116","source":"Crossref","is-referenced-by-count":30,"title":["Specimen self\u2010collection and HPV DNA screening in a pilot study of 100,242 women"],"prefix":"10.1002","volume":"135","author":[{"given":"Eduardo","family":"Lazcano\u2010Ponce","sequence":"first","affiliation":[{"name":"Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud P\u00fablica de M\u00e9xico. 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Cuernavaca Morelos  M\u00e9xico"},{"name":"Unidad de Investigacion Epidemiologica y en Servicios de Salud Instituto Mexicano del Seguro Social Cuernavaca Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud P\u00fablica de M\u00e9xico. Cuernavaca Morelos  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Rojas","sequence":"additional","affiliation":[{"name":"Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud P\u00fablica de M\u00e9xico. Cuernavaca Morelos  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud P\u00fablica de M\u00e9xico. 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Cuernavaca Morelos  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jfprhc.2011.0100"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70156-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1804"},{"key":"e_1_2_6_10_1","unstructured":"Hern\u00e1ndez\u2010AvilaM Lazcano\u2010PonceE Mart\u00ednezO.Public policies for HPV screening and vaccination in Mexico. 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