{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:09Z","timestamp":1761895809419},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:p>As hyperphosphorylated paratarg\u20107 (pP\u20107) carrier state was shown to be the first molecularly defined autosomal dominantly inherited risk factor for monoclonal gammopathy of unknown significance (MGUS) and multiple myeloma (MM) in a European population, the prevalence of pP\u20107 carrier state among African\u2010Americans who have a significantly higher incidence of MGUS\/MM is of interest. We therefore determined pP\u20107 carrier state and paraproteins with specificity for P\u20107 in African\u2010American, European and Japanese patients with MGUS\/MM and healthy controls. By isoelectric focusing and ELISA, a paratarg\u20107\u2010specific paraprotein and the associated pP\u20107 carrier state was observed in 30\/81 (37.0%) African\u2010American, 42\/252 (16.7%) European and 7\/176 (4.0%) Japanese MGUS\/MM patients (<jats:italic>p<\/jats:italic> &lt; 0.001). A pP\u20107 carrier state was found in 11\/100 (11.0%) African\u2010American, 8\/550 (1.5%) European and 1\/278 (0.4%) Japanese healthy controls (<jats:italic>p<\/jats:italic> &lt; 0.001), resulting in an odds ratio for MGUS\/MM of 4.8 (<jats:italic>p<\/jats:italic> &lt; 0.001) among African\u2010American, 13.6 among European (<jats:italic>p<\/jats:italic> &lt; 0.001) and 11.5 (<jats:italic>p<\/jats:italic> = 0.023) among Japanese carriers of pP\u20107. We conclude that pP\u20107 carriers are most prevalent among African\u2010Americans, but a pP\u20107 carrier state is the strongest molecularly defined single risk factor for MGUS\/MM known to date in all three ethnic groups. The high prevalence of pP\u20107 carriers among African\u2010American patients emphasizes a predominant role of this genetic factor in the pathogenesis of these diseases. The large number of pP7 African\u2010American patients and controls should facilitate the identification of the SNP or mutation underlying the pP\u20107 carrier state.<\/jats:p>","DOI":"10.1002\/ijc.28731","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T11:05:19Z","timestamp":1390215919000},"page":"934-938","source":"Crossref","is-referenced-by-count":12,"title":["Over one\u2010third of African\u2010American MGUS and multiple myeloma patients are carriers of hyperphosphorylated paratarg\u20107, an autosomal dominantly inherited risk factor for MGUS\/MM"],"prefix":"10.1002","volume":"135","author":[{"given":"Carsten","family":"Zwick","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I Jos\u00e9\u2010Carreras\u2010Center for Immuno and Gene Therapy Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Jos\u00e9\u2010Carreras\u2010Center for Immuno and Gene Therapy Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Auth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Jos\u00e9\u2010Carreras\u2010Center for Immuno and Gene Therapy Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Bernal\u2010Mizrachi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Winship Cancer Institute Emory University School of Medicine Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Roback","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Sunay","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Division of Clinical Research Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Radiation Life Science, Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Ziepert","sequence":"additional","affiliation":[{"name":"The Institute for Medical Informatics Statistics and Epidemiology (IMISE) Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Tumor Immunology Aichi Medical University Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pfreundschuh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Jos\u00e9\u2010Carreras\u2010Center for Immuno and Gene Therapy Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010Dieter","family":"Preuss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Jos\u00e9\u2010Carreras\u2010Center for Immuno and Gene Therapy Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-387324"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11810"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24427"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70234-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-306076"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351668"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.8062"},{"key":"e_1_2_6_9_1","first-page":"829","article-title":"Stomatin\u2010like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma","volume":"17","author":"Cui Z","year":"2007","journal-title":"Oncol Rep"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61090-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.134"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331454"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.28731","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.28731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:08:40Z","timestamp":1696522120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.28731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8,15]]}},"alternative-id":["10.1002\/ijc.28731"],"URL":"https:\/\/doi.org\/10.1002\/ijc.28731","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"type":"print","value":"0020-7136"},{"type":"electronic","value":"1097-0215"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}