{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:55Z","timestamp":1791276355554,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL094717"],"award-info":[{"award-number":["HL094717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>The purpose of these analyses is to test prospectively whether post\u2010diagnosis running and walking differ significantly in their association with breast cancer mortality. Cox proportional hazard analyses were used to compare breast cancer mortality to baseline exercise energy expenditure (METs, 1 MET\u2010hour \u22451 km run) in 272 runners and 714 walkers previously diagnosed with breast cancer from the National Runners' and Walkers' Health Studies when adjusted for age, race, menopause, family history, breastfeeding and oral contraceptive use. Diagnosis occurred (mean \u00b1 SD) 7.9 \u00b1 7.3 years before baseline. Forty\u2010six women (13 runners and 33 walkers) died from breast cancer during 9.1\u2010year mortality surveillance. For the 986 runners and walkers combined, breast cancer mortality decreased an average of 23.9% MET\u2010hours\/day [95% confidence interval (CI): 7.9\u201338.3%; <jats:italic>p<\/jats:italic> = 0.004]. There was a significantly greater decrease in risk for running than walking (risk per MET\u2010hours\/day run <jats:italic>vs<\/jats:italic>. walked: <jats:italic>p<\/jats:italic> = 0.03). For the 272 runners analyzed separately, breast cancer mortality decreased an average of 40.9% per MET\u2010hours\/day run (95% CI: 19.3\u201360.0%, <jats:italic>p<\/jats:italic> = 0.0004). When analyzed by categories of running energy expenditure, breast cancer mortality was 87.4% lower for the 1.8\u20133.6 MET\u2010hours\/day category (95% CI: 41.3\u201398.2% lower, <jats:italic>p<\/jats:italic> = 0.008) and 95.4% lower for the \u22653.6 MET\u2010hours\/day category (95% CI: 71.9\u2013100% lower, <jats:italic>p<\/jats:italic> = 0.0004) compared to the &lt;1.07 MET\u2010hours\/day category. In contrast, the 714 walkers showed a nonsignificant 4.6% decrease in breast cancer mortality per MET\u2010hours\/day walked (95% CI: 27.3% decreased risk to 21.3% increased risk, <jats:italic>p<\/jats:italic> = 0.71). These results suggest that post\u2010diagnosis running is associated with significantly lower breast cancer mortality than post\u2010diagnosis walking.<\/jats:p>","DOI":"10.1002\/ijc.28740","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T15:34:48Z","timestamp":1390836888000},"page":"1195-1202","source":"Crossref","is-referenced-by-count":31,"title":["Significantly greater reduction in breast cancer mortality from post\u2010diagnosis running than walking"],"prefix":"10.1002","volume":"135","author":[{"given":"Paul T.","family":"Williams","sequence":"first","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory Berkeley CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Cancer facts and figures, 2013","author":"American Cancer Society","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0771"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.20.2479"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.9822"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0295"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24155"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22201"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0595"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.6819"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1163.13.7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601820"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23747"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1770-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.01.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9536-x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009001-00009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300878"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182885f26"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31828121d0"},{"key":"e_1_2_6_21_1","article-title":"Reduced risk of brain cancer mortality from walking and running","author":"Williams PT","year":"2014","journal-title":"Med Sci Sports Exerc"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182a4e89c"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000142"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827b0d0a"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041906"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036360"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318258af3f"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065302"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080616"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440230063008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605163342004"},{"key":"e_1_2_6_32_1","unstructured":"Centers for Disease Control and Prevention. 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