{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:50:04Z","timestamp":1762375804169},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Cancer Foundation","award":["EMCR2008-4056"],"award-info":[{"award-number":["EMCR2008-4056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Ovarian cancer is the deadliest gynecological malignancy in Western countries. Early detection, however, is hampered by the fact that the origin of ovarian cancer remains unclear. Knowing that in a high percentage of endometrioid ovarian cancers Wnt\/\u03b2\u2010catenin signaling is activated, and in view of the hypothesis that ovarian cancer may originate from the distal oviduct, we studied mice in which Wnt\/\u03b2\u2010catenin signaling was activated in M\u00fcllerian duct\u2010derived tissues. Conditional adenomatous polyposis coli (<jats:italic>Apc<\/jats:italic>) knockout mice were used to study the activation of Wnt\/\u03b2\u2010catenin signaling in M\u00fcllerian duct\u2010derived organs. These <jats:italic>Pgr<\/jats:italic><jats:sup>Cre\/+<\/jats:sup>;<jats:italic>Apc<\/jats:italic><jats:sup>ex15lox\/lox<\/jats:sup> mice (<jats:italic>n<\/jats:italic>\u2009=\u200944) were sacrificed at 10, 20, 40 and 80 weeks and uterus, oviduct, ovaries and surrounding fat tissues were assessed using immunohistochemistry. Using nuclear \u03b2\u2010catenin staining, Wnt\/\u03b2\u2010catenin signaling activation was confirmed in the entire epithelium of the adult M\u00fcllerian duct (fimbriae, oviduct and endometrium), but was absent in ovarian surface epithelium cells (OSEs). Besides endometrial hyperplasia, in 87.2% of mice intraepithelial lesions of the distal oviduct were found, whereas OSEs remained unaffected. In addition, 62.5% of mice developed tumors in the distal and fimbrial part of the oviduct. In the ovaries, mainly at young age, in 16.3% of mice, simple epithelial cysts were noted, which developed further into endometrioid ovarian tumors, resembling human endometrioid ovarian cancer (27.9% of mice). Next to this, locoregional growth in the utero\u2010ovarian ligament was also shown. Here, for the first time, mutations (activation of Wnt\/\u03b2\u2010catenin) in the distal oviduct result in precursor lesions that develop into ovarian tumors, resembling human endometrioid ovarian cancer.<\/jats:p>","DOI":"10.1002\/ijc.28746","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:47:14Z","timestamp":1390992434000},"page":"1028-1037","source":"Crossref","is-referenced-by-count":22,"title":["A mouse model for endometrioid ovarian cancer arising from the distal oviduct"],"prefix":"10.1002","volume":"135","author":[{"given":"Paul H.","family":"van der Horst","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marten","family":"van der Zee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pathology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Heijmans\u2010Antonissen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yundan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pathology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco J.","family":"DeMayo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien H.M.","family":"van Deurzen","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia C.","family":"Ewing","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt W.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leen J.","family":"Blok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJSH BrayF FormanD et al.GLOBOCAN 2008 v2.0 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. 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