{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:53:10Z","timestamp":1789602790643,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T00:00:00Z","timestamp":1392076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan","award":["24600030, 22501002 and 24600029"],"award-info":[{"award-number":["24600030, 22501002 and 24600029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult\u2010onset CR influences the lifetime cancer risk in mice after early\u2010life exposure to ionizing radiation. Infant male mice (1\u2010week\u2010old) were exposed to 3.8 Gy X\u2010rays, fed a control 95 kcal\/week or CR 65 kcal\/week diet from 7 weeks of age (adult stage), and their lifespan and tumor development were assessed. Irrespective of CR, X\u2010rays shortened lifespan by 38%, and irrespective of irradiation CR extended lifespan by 20%. Thymic lymphoma (TL) and early\u2010occurring non\u2010TL were induced by radiation. The liver and Harderian gland were more susceptible to radiation\u2010induced tumors than the lungs and non\u2010thymic lymphoid tissues (late occurring). CR reduced the risk of hepatocellular carcinoma, late\u2010occurring non\u2010TL, lung tumor, Harderian tumor, and hemangioma but had less impact on TL and early\u2010occurring non\u2010TL. Most notably, the effects of X\u2010rays on induction of lung tumors, late\u2010occurring non\u2010TL and hemangioma were essentially canceled by CR. The ability of CR to prevent late\u2010occurring tumors was the same for non\u2010irradiated and irradiated mice, indicating that the mechanism by which CR influences cancer is independent of irradiation. Our results indicate that adult\u2010onset CR significantly inhibits late\u2010occurring tumors in a tissue\u2010dependent manner regardless of infant radiation exposure.<\/jats:p>","DOI":"10.1002\/ijc.28751","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T04:39:52Z","timestamp":1391143192000},"page":"1038-1047","source":"Crossref","is-referenced-by-count":37,"title":["Cancer prevention by adult\u2010onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice"],"prefix":"10.1002","volume":"135","author":[{"given":"Yi","family":"Shang","sequence":"first","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology Institute for Environmental Sciences Takahoko, Rokkasho Kamikita Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Morioka","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kokubo","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Tani","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takabatake","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Shimada","sequence":"additional","affiliation":[{"name":"Radiobiology for Children's Health Program National Institute of Radiological Sciences Inage\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2629.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9124744"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/359021a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn045"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507871686"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-006-9003-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-9728.2003.00033.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(77)90043-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(92)90012-O"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173635"},{"key":"e_1_2_7_13_1","first-page":"55","article-title":"Influence of caloric intake on experimental carcinogenesis: a review","volume":"206","author":"Kritchevsky D","year":"1986","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_7_14_1","first-page":"724","article-title":"The influence of the degree of caloric restriction on the formation of skin tumors and hepatomas in mice","volume":"9","author":"Tannenbaum A","year":"1949","journal-title":"Cancer Res"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230611"},{"key":"e_1_2_7_16_1","first-page":"1463","article-title":"Inhibition of the development of tumors or leukemia in mice and rats after reduction of food intake","volume":"62","author":"Gross L","year":"1988","journal-title":"Possible implications for humans. 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