{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:09:06Z","timestamp":1773853746362,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Academia Sinica, Taipei, Taiwan"},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb Co., USA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Roche Diagnostics Ltd., Switzerland"},{"name":"the Department of Health, Executive Yuan, Taipei, Taiwan"},{"name":"the National Health Research Institutes, Chunan, Taiwan","award":["NHRI-EX98-9806PI"],"award-info":[{"award-number":["NHRI-EX98-9806PI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case\u2013control and cohort studies. In the case\u2013control study, 397 HCC cases from medical centers were compared with 410 community\u2010based non\u2010HCC controls. All of them were anti\u2010HCV\u2010seropositive, HBsAg\u2010seronegative with serum HCV RNA levels \u22651,000 IU\/mL. Logistic regression models were used to estimate the odds ratio (OR) with 95% confidence interval (95% CI) of HCV subtype after controlling for other HCC risk factors. In the cohort study, 866 anti\u2010HCV\u2010seropositive individuals were followed from 1991 to 2008 to assess the long\u2010term HCC predictability of HCV subtypes. Newly developed HCC cases were ascertained by follow\u2010up health examinations and computerized linkage with national databases. The percentage of HCV 1b subtype was higher among HCC cases than controls (64<jats:italic>vs<\/jats:italic>. 55%,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Participant infected with HCV 1b had a higher mean serum HCV RNA level (2.0 \u00d7 10<jats:sup>6<\/jats:sup>IU\/mL) than those infected with HCV non\u20101b (1.2 \u00d7 10<jats:sup>6<\/jats:sup>IU\/mL,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The multivariate\u2010adjusted OR (95% CI) of developing HCC for HCV 1b comparing to non\u20101b was 1.43 (1.02\u20132.02). After the long\u2010term follow\u2010up, the cumulative lifetime (30\u201380 years old) HCC risk was 19.2 and 29.7% for patients infected with HCV non\u20101b and 1b, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The multivariate\u2010adjusted hazard ratio (95% CI) was 1.85 (1.06\u20133.22) for HCV 1b compared to non\u20101b. HCV subtype 1b, the most prevalent subtype in Taiwan, was associated with an increased HCC risk and a proactive clinical management is suggested for patients with HCV 1b.<\/jats:p>","DOI":"10.1002\/ijc.28753","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T10:57:52Z","timestamp":1391165872000},"page":"1119-1126","source":"Crossref","is-referenced-by-count":56,"title":["Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma"],"prefix":"10.1002","volume":"135","author":[{"given":"Mei\u2010Hsuan","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwai\u2010I","family":"Yang","sequence":"additional","affiliation":[{"name":"Genomics Research Center Academia Sinica Taipei Taiwan"},{"name":"Molecular and Genomic Epidemiology Center China Medical University Hospital 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