{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:30:45Z","timestamp":1787614245340,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, the therapeutic stronghold is sorafenib, a tyrosine kinase inhibitor (TKI) directed against the vascular endothelial growth factor (VEGF) family. Previous observations suggested that polymorphisms of VEGF and its receptor (VEGFR) genes may regulate angiogenesis and lymphangiogenesis and thus tumour growth control. The aim of our study was to evaluate the role of VEGF and VEGFR polymorphisms in determining the clinical outcome of HCC patients receiving sorafenib. From a multicentre experience 148 samples (tumour or blood samples) of HCC patients receiving sorafenib were tested for VEGF\u2010A, VEGF\u2010C and VEGFR\u20101,2,3 single nucleotide polymorphisms (SNPs). Patients' progression\u2010free survival (PFS) and overall survival (OS) were analysed. At univariate analysis VEGF\u2010A alleles C of rs25648, T of rs833061, C of rs699947, C of rs2010963, VEGF\u2010C alleles T of rs4604006, G of rs664393, VEGFR\u20102 alleles C of rs2071559, C of rs2305948 were significant predictors of PFS and OS. At multivariate analysis rs2010963, rs4604006 and BCLC (Barcelona Clinic Liver Cancer) stage resulted to be independent factors influencing PFS and OS. Once prospectively validated, the analysis of VEGF and VEGFR SNPs may represent a clinical tool to better identify HCC patients more likely to benefit from sorafenib. On the other hand, the availability of more accurate predictive factors could help avoiding unnecessary toxicities to potentially resistant patients who may be optimal candidates for different treatments interfering with other tumour molecular pathways.<\/jats:p>","DOI":"10.1002\/ijc.28772","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T06:51:59Z","timestamp":1391842319000},"page":"1247-1256","source":"Crossref","is-referenced-by-count":117,"title":["VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: The ALICE\u20101 study"],"prefix":"10.1002","volume":"135","author":[{"given":"Mario","family":"Scartozzi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Translational Oncology Unit AOU Ospedali Riuniti Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Faloppi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Translational Oncology Unit AOU Ospedali Riuniti Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Svegliati Baroni","sequence":"additional","affiliation":[{"name":"Clinica di Gastroenterologia AOU Ospedali Riuniti Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Loretelli","sequence":"additional","affiliation":[{"name":"Cancer Genetics Program Beth Israel Deaconess Medical Center Boston MA"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center Boston MA"},{"name":"Department of Pathology Beth Israel Deaconess Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Piscaglia","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Iavarone","sequence":"additional","affiliation":[{"name":"A.M. &amp; A. 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