{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:08:41Z","timestamp":1773259721809,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Portuguese Foundation of Science and Technology (FCT)","award":["ref. SFRH\/BPD\/62974\/2009"],"award-info":[{"award-number":["ref. SFRH\/BPD\/62974\/2009"]}]},{"name":"Council of Rectors of Portuguese Universities (CRUP)","award":["Luso-Espanholas E-83\/10"],"award-info":[{"award-number":["Luso-Espanholas E-83\/10"]}]},{"name":"Fundaci\u00ef\u00bf\u00bd LaCaixa","award":["ref. BM06-130-0"],"award-info":[{"award-number":["ref. 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Despite the evidence pointing to the <jats:italic>IL1<\/jats:italic> region, definite functional variants reproducible across populations of different genetic background have not been discovered so far. A high density linkage disequilibrium (LD) map of the <jats:italic>IL1<\/jats:italic> gene cluster was established using HapMap to identify haplotype tagSNPs. Eighty\u2010seven SNPs were genotyped in a Portuguese case\u2010control study (358 cases, 1,485 controls) for the discovery analysis. A replication study, including a subset of those tagSNPs (43), was performed in an independent analysis (EPIC\u2010EurGast) containing individuals from 10 European countries (365 cases, 1284 controls). Single SNP and haplotype block associations were determined for GC overall and anatomopathological subtypes. The most robust association was observed for SNP rs17042407, 16Kb upstream of the <jats:italic>IL1A<\/jats:italic> gene. Although several other SNP associations were observed, only the inverse association of rs17042407 allele C with GC of the intestinal type was observed in both studies, retaining significance after multiple testing correction (<jats:italic>p<\/jats:italic>\u2009=\u20090.0042) in the combined analysis. The haplotype analysis of the <jats:italic>IL1A<\/jats:italic> LD block in the combined dataset revealed the association between a common haplotype carrying the rs17042407 variant and GC, particularly of the intestinal type (<jats:italic>p<\/jats:italic>\u2009=\u20093.1 \u00d7 10<jats:sup>\u22125<\/jats:sup>) and non cardia localisation (<jats:italic>p<\/jats:italic>\u2009=\u20094.6 \u00d7 10<jats:sup>\u22123<\/jats:sup>). These results confirm the association of <jats:italic>IL1<\/jats:italic> gene variants with GC and reveal a novel SNP and haplotypes in the <jats:italic>IL1A<\/jats:italic> region associated with intestinal type GC in European populations.<\/jats:p>","DOI":"10.1002\/ijc.28776","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:21:48Z","timestamp":1392207708000},"page":"1343-1355","source":"Crossref","is-referenced-by-count":13,"title":["Genetic variants in the <i>IL1A<\/i> gene region contribute to intestinal\u2010type gastric carcinoma susceptibility in European populations"],"prefix":"10.1002","volume":"135","author":[{"given":"Cec\u00edlia","family":"Dur\u00e3es","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Group Translational Research Laboratory, Catalan Institute of Oncology (IDIBELL) Barcelona Spain"},{"name":"Hereditary Cancer Program Translational Research Laboratory, Catalan Institute of Oncology (ICO\u2010IDIBELL) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Bonet","sequence":"additional","affiliation":[{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology (IDIBELL) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Group Translational Research Laboratory, Catalan Institute of Oncology (IDIBELL) Barcelona Spain"},{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology (IDIBELL) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adoraci\u00f3n","family":"Vencesl\u00e1","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Group Translational Research Laboratory, Catalan Institute of Oncology (IDIBELL) Barcelona Spain"},{"name":"Unit of Nutrition Environment and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology (IDIBELL) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) Porto Portugal"},{"name":"Faculty of Medicine of the University of Porto Porto Portugal"},{"name":"Department of Pathology Hospital of S. Jo\u00e3o Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the University of Porto Porto Portugal"},{"name":"Institute of Public Health of the University of Porto (ISPUP) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the University of Porto Porto Portugal"},{"name":"Institute of Public Health of the University of Porto (ISPUP) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Barros","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of the University of Porto Porto Portugal"},{"name":"Institute of Public Health of the University of Porto (ISPUP) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Lindkvist","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team Villejuif France"},{"name":"Universit\u00e9 Paris\u2010Sud UMRS 1018 Villejuif France"},{"name":"Institut Gustave Roussy (IGR) Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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