{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:41:19Z","timestamp":1787146879568,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA047473"],"award-info":[{"award-number":["R01 CA047473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K05 CA157439"],"award-info":[{"award-number":["K05 CA157439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10 CA13539"],"award-info":[{"award-number":["U10 CA13539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10 CA98543"],"award-info":[{"award-number":["U10 CA98543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Childrens Cancer Research Fund, Minneapolis, MN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:p>An infectious origin for pediatric Hodgkin lymphoma (HL) has long been suspected and Epstein\u2010Barr virus (EBV) has been implicated in a subset of cases. Increased HL incidence in children with congenital and acquired immunodeficiencies, consistent associations between autoimmune diseases and adult HL and genome\u2010wide association and other genetic studies together suggest immune dysregulation is involved in lymphomagenesis. Here, healthy control children identified by random digit dialing were matched on sex, race\/ethnicity and age to HL diagnosed in 1989\u20132003 at 0\u201314 years at Children's Oncology Group institutions. Parents of 517 cases and 784 controls completed telephone interviews, including items regarding medical histories. Tumor EBV status was determined for 355 cases. Using conditional logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) for risk of HL. Cases were more likely to have had an infection &gt;1 year prior to HL diagnosis (OR\u2009=\u20091.69, 95% CI: 0.98\u20132.91); case siblings were also more likely to have had a prior infection (OR\u2009=\u20092.04, 95% CI: 1.01\u20134.14). Parental history of autoimmunity associated with increased EBV+ HL risk (OR\u2009=\u20092.97, 95% CI: 1.34\u20136.58), while having a parent (OR\u2009=\u20091.47, 95% CI: 1.01\u20132.14) or sibling (OR\u2009=\u20091.62, 95% CI: 1.11\u20132.36) with an allergy was associated with EBV\u2009\u2212\u2009HL. These results may indicate true increased risk for infections and increased risk with family history of autoimmune and allergic conditions that varies by tumor EBV status, or they may be attributable to inaccurate recall. In addition to employing biomarkers to confirm the role of immune\u2010modulating conditions in pediatric HL, future studies should focus on family based designs.<\/jats:p>","DOI":"10.1002\/ijc.28785","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T10:06:45Z","timestamp":1392286005000},"page":"1454-1469","source":"Crossref","is-referenced-by-count":27,"title":["Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: A Children's Oncology Group study"],"prefix":"10.1002","volume":"135","author":[{"given":"Amy M.","family":"Linabery","sequence":"first","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research Department of Pediatrics, University of Minnesota Minneapolis Minnesota"},{"name":"University of Minnesota Masonic Cancer Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik B.","family":"Erhardt","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of New Mexico Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Fonstad","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research Department of Pediatrics, University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Ambinder","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta R.","family":"Bunin","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research Department of Pediatrics, University of Minnesota Minneapolis Minnesota"},{"name":"University of Minnesota Masonic Cancer Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan G.","family":"Spector","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research Department of Pediatrics, University of Minnesota Minneapolis Minnesota"},{"name":"University of Minnesota Masonic Cancer Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seymour","family":"Grufferman","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics, and Preventive Medicine Department of Internal Medicine, University of New Mexico Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (www.seer.cancer.gov)SEER*Stat Database: Incidence \u2010 SEER 13 Regs Research Data Nov 2011 Sub Vintage 2009 Pops (1992\u20132009) <Katrina\/Rita Population Adjustment> \u2013 Linked To County Attributes \u2013 Total U.S. 1969\u20132010 Counties National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2012 based on the November 2011 submission. Available at:www.seer.cancer.gov. (Accessed on November 20 2012)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198722000-00017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.2.205"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401097"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws212"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970917)72:6<977::AID-IJC10>3.0.CO;2-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300409"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101153040302"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903163201103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200806"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2342"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1983.15.issue-4.03"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.231"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2404"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010512"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24287"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr516"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039986"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1200\/JCO.1984.2.6.670","article-title":"An approach to conducting epidemiologic research within cooperative clinical trials groups","volume":"2","author":"Grufferman S","year":"1984","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.2.462.462"},{"key":"e_1_2_7_23_1","unstructured":"GaudermanWJ MorrisonJM.QUANTO 1.1: a computer program for power and sample size calculations for genetic\u2010epidemiology studies. Available at:http:\/\/hydra.usc.edu\/gxe. (Last updated in June 2009.)"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.07.027"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1995.02170180083016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pubmed.a042571"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603999"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-12780-9_2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200106000-00009"},{"key":"e_1_2_7_30_1","first-page":"500","article-title":"Detection of human herpesvirus\u20106 and Epstein\u2010Barr virus genome in childhood Hodgkin's disease","volume":"86","author":"Trovato R","year":"1994","journal-title":"Pathologica"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09206.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-306274"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25862"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9294-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1236.13.7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1049"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10939"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1104"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken051"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.12.010"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1361.13.8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.02.019"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000083033.56116.c1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.54.6.431"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.04.021"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209601"},{"key":"e_1_2_7_48_1","unstructured":"Centers for Disease Control and Prevention. National Center for Health Statistics. Health Data Interactive. Allergic conditions ages 0\u201317: US 1997\u20132011; Asthma and chronic obstructive pulmonary disease: US 1997\u20132011 (Source: NHIS). Hyattsville MD: National Center for Health Statistics; 2013. Available at:www.cdc.gov\/nchs.hdi.htm. (Accessed on March 25 2013)."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22702"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309148528"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12117861"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.28785","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.28785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T19:48:20Z","timestamp":1722109700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.28785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,18]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,9,15]]}},"alternative-id":["10.1002\/ijc.28785"],"URL":"https:\/\/doi.org\/10.1002\/ijc.28785","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,18]]}}}