{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:18Z","timestamp":1788872358368,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The State Key Project Specialized for Infectious Diseases of China","award":["2012ZX10002008-002"],"award-info":[{"award-number":["2012ZX10002008-002"]}]},{"name":"The United States National Institutes of Health","award":["R37 CA070867"],"award-info":[{"award-number":["R37 CA070867"]}]},{"name":"The State Key Project Specialized for Infectious Diseases of China","award":["2008ZX10002-015"],"award-info":[{"award-number":["2008ZX10002-015"]}]},{"name":"The United States National Institutes of Health","award":["R01 CA82729"],"award-info":[{"award-number":["R01 CA82729"]}]},{"name":"The United States National Institutes of Health","award":["R01 HL095931"],"award-info":[{"award-number":["R01 HL095931"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    Uncertainty remains on the relationship between a family history of liver cancer and liver cancer risk in prospective cohort studies in a general population. Thus, we examined this association in 133,014 participants in the Shanghai Women's and Men's Health Studies. Family history of liver cancer was categorized through dichotomous and proportional score approaches. Hazard ratios (HRs) and 95% confidence intervals (CIs) were derived using the Cox proportional hazards models with adjustment for potential confounders. A meta\u2010analysis of observational studies through December 2013 on liver cancer risk in relation to family history of liver cancer was also performed. Study\u2010specific risk estimates were combined using fixed or random effects models depending on whether significant heterogeneity was detected. For the Shanghai Women's and Men's Health Studies, 299 liver cancer cases were identified during follow\u2010up through 2010. Family history of liver cancer was associated with liver cancer risk using both binary indicator (HR\u2009=\u20092.60, 95% CI: 1.77\u20133.80) and proportional score (high\u2010risk\n                    <jats:italic>vs<\/jats:italic>\n                    . minimal\u2010risk category: HR\u2009=\u20093.03, 95% CI: 1.73\u20135.31), with increasing HRs for increasing score categories. The meta\u2010analysis also showed an increased risk for those with a family history of liver cancer (relative risk\u2009=\u20092.55, 95% CI: 2.05\u20133.16). Family history of liver cancer was related to increased risk of liver cancer in Chinese population. This risk is particularly high for those with an affected mother. The \u201cdose\u2010response\u201d of risk with an increasing family history score of liver cancer might further facilitate future cancer prevention programs on identifying individuals with the highest potential liver cancer risk.\n                  <\/jats:p>","DOI":"10.1002\/ijc.28792","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T07:14:55Z","timestamp":1392707695000},"page":"1605-1614","source":"Crossref","is-referenced-by-count":24,"title":["Prospective cohort studies of association between family history of liver cancer and risk of liver cancer"],"prefix":"10.1002","volume":"135","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai 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Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt Epidemiology Center, Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt Epidemiology Center, Vanderbilt\u2010Ingram Cancer Center, Vanderbilt University School of Medicine Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai 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