{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:14:58Z","timestamp":1771168498574,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Baseline human papillomavirus (HPV) prevalence and type distribution were evaluated in young Chinese women enrolled in a clinical trial of an HPV vaccine (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> registration NCT00779766). Cervical specimens and blood samples were collected at baseline from women aged 18\u201325 years (<jats:italic>n<\/jats:italic>\u2009=\u20096,051) from four sites across Jiangsu province. Cervical specimens were tested for HPV DNA by SPF<jats:sub>10<\/jats:sub> PCR\u2010DEIA\u2010LiPA<jats:sub>25<\/jats:sub> version 1, and HPV\u201016\/18 type\u2010specific polymerase chain reaction. Anti\u2010HPV\u201016 and anti\u2010HPV\u201018 antibody titres were quantified by enzyme\u2010linked immunosorbent assay. At baseline, 15.3% of women were DNA positive for any of 14 HPV high\u2010risk (hr) types (HPV\u201016\/18\/31\/33\/35\/39\/45\/51\/52\/56\/58\/59\/66\/68). The most commonly detected hrHPV types in cervical specimens were HPV\u201052 (4.0%) and HPV\u201016 (3.7%). High\u2010risk HPV DNA\u2010positivity increased with severity of cytological abnormalities: 39.3% in atypical squamous cells of undetermined significance, 85.0% in low\u2010grade squamous intraepithelial lesions and 97.8% in high\u2010grade squamous intraepithelial lesions (HSIL). The hrHPV types most frequently detected in HSIL were HPV\u201016 (63.0%), HPV\u201018 (17.4%), HPV\u201052 (17.4%), HPV\u201058 (15.2%) and HPV\u201033 (15.2%). The hrHPV types most frequently detected in cervical intraepithelial neoplasia 2+ were HPV\u201016 (66.1%), HPV\u201033 (16.1%), HPV\u201052 (16.1%), HPV\u201058 (14.5%) and HPV\u201051 (11.3%). Multiple hrHPV infections were reported for 24.4% of hrHPV DNA positive women. Regardless of baseline HPV DNA status, 30.5% and 16.0% of subjects were initially seropositive for anti\u2010HPV\u201016 and anti\u2010HPV\u201018, respectively. In conclusion, the high baseline seropositivity rate and intermediate prevalence of cervical hrHPV types in Chinese women aged 18\u201325 years underlines the importance of early HPV vaccination in this population.<\/jats:p>","DOI":"10.1002\/ijc.28896","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T09:10:35Z","timestamp":1397725835000},"page":"2604-2611","source":"Crossref","is-referenced-by-count":28,"title":["Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18\u201325 years enrolled in a clinical trial"],"prefix":"10.1002","volume":"135","author":[{"given":"Fang\u2010Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Cancer Institute and Hospital Chinese Academy of Medical Sciences (CICAMS) and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Cai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Province Center for Disease Prevention and Control Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Institute and Hospital Chinese Academy of Medical Sciences (CICAMS) and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute for Food and Drug Control Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangsu Province Center for Disease Prevention and Control Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hong","sequence":"additional","affiliation":[{"name":"The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Province Center for Disease Prevention and Control Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin\u2010Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Cancer Institute and Hospital Chinese Academy of Medical Sciences (CICAMS) and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Lianshui Center for Disease Prevention and Control Lianshui Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Institute and Hospital Chinese Academy of Medical Sciences (CICAMS) and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Xuzhou Center for Disease Prevention and Control Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwen","family":"Tang","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Vaccines Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Zhang","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Durand","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Vaccines Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjoy K.","family":"Datta","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Vaccines Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Struyf","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Vaccines Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Bi","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Vaccines Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the HPV\u2010039 study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ ShinHR BrayF et al. 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