{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:08:45Z","timestamp":1778134125242,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research","award":["23790800"],"award-info":[{"award-number":["23790800"]}]},{"DOI":"10.13039\/501100009029","name":"A-STEP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005928","name":"Daiwa Securities Health Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005928","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP\u2010high colorectal cancers (CRCs) with <jats:italic>BRAF<\/jats:italic> mutation are considered to arise from serrated pathway. We recently reported that microRNA\u201031 (miR\u201031) is associated with <jats:italic>BRAF<\/jats:italic> mutation in colorectal tumors. Emerging new approaches have revealed gradual changes in <jats:italic>BRAF<\/jats:italic> mutation and CIMP\u2010high throughout the colorectum in CRCs. Here, we attempted to identify a possible association between miR\u201031 and epigenetic features in serrated pathway, and hypothesized that miR\u201031 supports the \u201ccolorectal continuum\u201d concept. We evaluated miR\u201031 expression, <jats:italic>BRAF<\/jats:italic> mutation and epigenetic features including CIMP status in 381 serrated lesions and 222 non\u2010serrated adenomas and examined associations between them and tumor location (rectum; sigmoid, descending, transverse and ascending colon and cecum). A significant association was observed between high miR\u201031 expression and CIMP\u2010high status in serrated lesions with <jats:italic>BRAF<\/jats:italic> mutation (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). In contrast, miR\u201031 was slightly but insignificantly associated with CIMP status in the cases with wild\u2010type <jats:italic>BRAF<\/jats:italic>. miR\u201031 expression in sessile serrated adenomas (SSAs) with cytological dysplasia was higher than that in SSAs, whereas, no significant difference was observed between traditional serrated adenomas (TSAs) and TSAs with high\u2010grade dysplasia. The frequency of miR\u201031, <jats:italic>BRAF<\/jats:italic> mutation CIMP\u2010high and <jats:italic>MLH1<\/jats:italic> methylation increased gradually from the rectum to cecum in serrated lesions. In conclusion, miR\u201031 expression was associated with CIMP\u2010high status in serrated lesions with <jats:italic>BRAF<\/jats:italic> mutation. Our data also suggested that miR\u201031 plays an important role in SSA evolution and may be a molecule supporting the colorectal continuum.<\/jats:p>","DOI":"10.1002\/ijc.28920","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T07:56:42Z","timestamp":1397980602000},"page":"2507-2515","source":"Crossref","is-referenced-by-count":43,"title":["MicroRNA\u201031 expression in relation to <i>BRAF<\/i> mutation, CpG island methylation and colorectal continuum in serrated lesions"],"prefix":"10.1002","volume":"135","author":[{"given":"Miki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayoshi","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Nosho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Keiyukai Sapporo Hospital  Sapporo Japan"},{"name":"Department of Gastroenterology NTT East Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Keiyukai Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pathology Keiyukai Sapporo Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Sukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Medical Genome Sciences Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tokino","sequence":"additional","affiliation":[{"name":"Department of Medical Genome Sciences Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Graduate School of Medical Science, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reo","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Sapporo 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