{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:24:47Z","timestamp":1789809887200,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Belgian Fund for Medical Scientific Research, The Centre Anti-Cancereux pr\u00e8s l'Universit\u00e9 de Li\u00e8ge, The Faculty of Medicine of the University of Li\u00e8ge"},{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"crossref","award":["1R21CA173190-01"],"award-info":[{"award-number":["1R21CA173190-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Fonds L\u00e9on Fr\u00e9d\u00e9ricq"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamocolumnar junction (SCJ) and suggest that these cells may not regenerate after excision (loop electrosurgical excision procedure). Our study addressed the impact of SCJ excision on the temporal dynamics, histologic and viral (human papillomavirus, HPV) characteristics of recurrent CIN. One hundred and thirty\u2010one consecutive patients treated by excision and attending follow\u2010up visits were enrolled. We compared recurrent and initial CIN with attention to excision margins, timing of recurrence, CIN grade, HPV types, p16 immunophenotype and SCJ immunophenotype. During the follow\u2010up period (up to 4 years), 16 (12.2%) recurrences were identified. Four (25%) were identified at the first follow\u2010up visit, closely resembled the initial CIN 2\/3 in grade and HPV type and were typically SCJ marker positive [SCJ(+)], suggesting nonexcised (residual) disease. Twelve (75%) manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were classified as CIN 1 and were SCJ (\u2212). In total, 9 out of 11 SCJ (\u2212) recurrences (82%) followed regressed spontaneously. Taken together, these results show that new lesions developing from any HPV infection are delayed and occur within the ectocervix or metaplastic epithelium. This markedly lower risk of CIN 2\/3 after successful SCJ excision suggests that the removal of the SCJ could be a critical variable in reducing the risk of subsequent CIN 2\/3 and cervical cancer.<\/jats:p>","DOI":"10.1002\/ijc.28978","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T17:03:07Z","timestamp":1400259787000},"page":"1043-1052","source":"Crossref","is-referenced-by-count":30,"title":["Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction"],"prefix":"10.1002","volume":"136","author":[{"given":"Michael","family":"Herfs","sequence":"first","affiliation":[{"name":"Department of Pathology, Laboratory of Experimental Pathology GIGA\u2010Cancer University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Somja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory of Experimental Pathology 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