{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:54:10Z","timestamp":1790704450259,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"crossref","award":["MFAG 11831"],"award-info":[{"award-number":["MFAG 11831"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>MC1R<\/jats:italic>\n                    gene is a key regulator of skin pigmentation. We aimed to evaluate the association between\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants and the risk of sporadic cutaneous melanoma (CM) within the M\u2010SKIP project, an international pooled\u2010analysis on\n                    <jats:italic>MC1R<\/jats:italic>\n                    , skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a summary odds ratio (SOR) for the association of each of the nine most studied\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants and of variants combined with CM by using random\u2010effects models. Stratified analysis by phenotypic characteristics were also performed. Melanoma risk increased with presence of any of the main\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants: the SOR for each variant ranged from 1.47 (95%CI: 1.17\u20131.84) for V60L to 2.74 (1.53\u20134.89) for D84E. Carriers of any\n                    <jats:italic>MC1R<\/jats:italic>\n                    variant had a 66% higher risk of developing melanoma compared with wild\u2010type subjects (SOR; 95%CI: 1.66; 1.41\u20131.96) and the risk attributable to\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants was 28%. When taking into account phenotypic characteristics, we found that\n                    <jats:italic>MC1R<\/jats:italic>\n                    \u2010associated melanoma risk increased only for darker\u2010pigmented Caucasians: SOR (95%CI) was 3.14 (2.06\u20134.80) for subjects with no freckles, no red hair and skin Type III\/IV. Our study documents the important role of all the main\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants in sporadic CM and suggests that they have a direct effect on melanoma risk, independently on the phenotypic characteristics of carriers. This is of particular importance for assessing preventive strategies, which may be directed to darker\u2010pigmented Caucasians with\n                    <jats:italic>MC1R<\/jats:italic>\n                    variants as well as to lightly pigmented, fair\u2010skinned subjects.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29018","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T10:06:37Z","timestamp":1402394797000},"page":"618-631","source":"Crossref","is-referenced-by-count":110,"title":["<i>MC1R<\/i>\n                    variants increased the risk of sporadic cutaneous melanoma in darker\u2010pigmented\n                    <scp>C<\/scp>\n                    aucasians: A pooled\u2010analysis from the M\u2010SKIP project"],"prefix":"10.1002","volume":"136","author":[{"given":"Elena","family":"Pasquali","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Biostatistics European Institute of Oncology Milan 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Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Nijsten","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Department of Dermatology Instituto Valenciano de Oncologia Valencia Spain"},{"name":"Universidad Cat\u00f3lica de Valencia  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Cancer Center Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Kanetsky","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ghiorzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties University of Genoa  Italy"},{"name":"Genetics of Rare Hereditary Cancers IRCCS AOU San Martino \u2013IST  Genoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Debniak","sequence":"additional","affiliation":[{"name":"Department of Genetic and Pathology Pomeranian Medical University Polabska Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Branicki","sequence":"additional","affiliation":[{"name":"Institute of Forensic Research Krakow 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Laurin","family":"Council","sequence":"additional","affiliation":[{"name":"Division of Dermatology Washington University School of Medicine St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Autier","sequence":"additional","affiliation":[{"name":"International Prevention Research Institute Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Community Medicine University of Ottawa  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Newton\u2010Bishop","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics Institute of Cancer and Pathology, University of Leeds  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sera","sequence":"additional","affiliation":[{"name":"UCL Institute of Child Health London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the M\u2010SKIP Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ ShinHR BrayF et al. 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