{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:45:16Z","timestamp":1791319516954,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UM-MoHE High Impact Research Grant","award":["UM.C\/625\/1\/1HIR\/282 MoHE\/CHAN-02 (H50001-A000023)"],"award-info":[{"award-number":["UM.C\/625\/1\/1HIR\/282 MoHE\/CHAN-02 (H50001-A000023)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    Nasopharyngeal carcinoma (NPC) arises from the mucosal epithelium of the nasopharynx and is constantly associated with Epstein\u2013Barr virus type 1 (EBV\u20101) infection. We carried out a genome\u2010wide association study (GWAS) of 575,247 autosomal SNPs in 184 NPC patients and 236 healthy controls of Malaysian Chinese ethnicity. Potential association signals were replicated in a separate cohort of 260 NPC patients and 245 healthy controls. We confirmed the association of\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    to NPC with the strongest signal detected in rs3869062 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.73 \u00d7 10\n                    <jats:sup>\u22129<\/jats:sup>\n                    ).\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    fine mapping revealed associations in the amino acid variants as well as its corresponding SNPs in the antigen peptide binding groove (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>HLA\u2010A\u2010aa\u2010site\u201099<\/jats:sub>\n                    \u2009=\u20093.79 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>rs1136697<\/jats:sub>\n                    \u2009=\u20093.79 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ) and T\u2010cell receptor binding site (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>HLA\u2010A\u2010aa\u2010site\u2010145<\/jats:sub>\n                    \u2009=\u20091.41 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>rs1059520<\/jats:sub>\n                    \u2009=\u20091.41 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    ) of the\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    . We also detected strong association signals in the 5\u2032\u2010UTR region with predicted active promoter states (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>rs41545520<\/jats:sub>\n                    \u2009=\u20097.91 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ). SNP rs41545520 is a potential binding site for repressor ATF3, with increased binding affinity for rs41545520\u2010G correlated with reduced\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    expression. Multivariate logistic regression diminished the effects of\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    amino acid variants and SNPs, indicating a correlation with the effects of\n                    <jats:italic>HLA\u2010A*11:01<\/jats:italic>\n                    , and to a lesser extent\n                    <jats:italic>HLA\u2010A*02:07<\/jats:italic>\n                    . We report the strong genetic influence of\n                    <jats:italic>HLA\u2010A<\/jats:italic>\n                    on NPC susceptibility in the Malaysian Chinese.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29035","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T07:43:20Z","timestamp":1403250200000},"page":"678-687","source":"Crossref","is-referenced-by-count":49,"title":["<i>HLA\u2010A<\/i>\n                    SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese"],"prefix":"10.1002","volume":"136","author":[{"given":"Yoon\u2010Ming","family":"Chin","sequence":"first","affiliation":[{"name":"Laboratory for International Alliance RIKEN Center for Genomic Medicine, Tsurumi\u2010ku Yokohama Kanagawa 230\u20100045 Japan"},{"name":"Institute of Biological Sciences, Faculty of Science University of Malaya Kuala Lumpur 50603 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Mushiroda","sequence":"additional","affiliation":[{"name":"Laboratory for Pharmacogenetics RIKEN Center for Genomic Medicine, Tsurumi\u2010ku Yokohama Kanagawa 230\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis RIKEN Center for Genomic Medicine Minato\u2010ku Tokyo 108\u20138639 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Kubo","sequence":"additional","affiliation":[{"name":"Laboratory for Genotyping Development RIKEN Center for Genomic Medicine, Tsurumi\u2010ku Yokohama Kanagawa 230\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopala","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee\u2010Fah","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Biomedical Sciences and Oral Cancer Research and Coordinating Centre Faculty of Dentistry University of Malaya Kuala Lumpur 50603 Malaysia"},{"name":"Cancer Research Initiatives Foundation Sime Darby Medical Centre Subang Jaya 47500 Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Hwang","family":"Teo","sequence":"additional","affiliation":[{"name":"Cancer Research Initiatives Foundation Sime Darby Medical Centre Subang Jaya 47500 Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Vey\u2010Hong","family":"Lim","sequence":"additional","affiliation":[{"name":"Tung Shin Hospital, Jalan Pudu Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoke\u2010Yeow","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 Malaysia"},{"name":"Department of Otorhinolaryngology Hospital Kuala Lumpur Kuala Lumpur 50586 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin\u2010Choo","family":"Pua","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital Pulau Pinang Penang 10990 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Kamatani","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis RIKEN Center for Genomic Medicine Minato\u2010ku Tokyo 108\u20138639 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Chicago Chicago IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon\u2010Kook","family":"Sam","sequence":"additional","affiliation":[{"name":"Natural Sciences and Science Education AG, National Institute of Education Nanyang Technological University, Singapore 637616 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Soo\u2010Beng","family":"Khoo","sequence":"additional","affiliation":[{"name":"Molecular Pathology Unit, Cancer Research Centre Institute for Medical Research Kuala Lumpur 50588 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Malaysian NPC Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Ching","family":"Ng","sequence":"additional","affiliation":[{"name":"Laboratory for International Alliance RIKEN Center for Genomic Medicine, Tsurumi\u2010ku Yokohama Kanagawa 230\u20100045 Japan"},{"name":"Institute of Biological Sciences, Faculty of Science University of Malaya Kuala Lumpur 50603 Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cancer incidence in five continents, vol. IX","author":"Curado MP","year":"2013"},{"key":"e_1_2_7_3_1","unstructured":"Zainal AriffinO NorSalehaIT et al. eds. National Cancer Registry Report 2007 Ministry of Health Malaysia 2011."},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1158\/1055-9965.482.13.3","article-title":"High incidence of nasopharyngeal carcinoma in native people of Sarawak, Borneo Island","volume":"13","author":"Devi BC","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360505"},{"key":"e_1_2_7_6_1","first-page":"2967","article-title":"Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chinese","volume":"43","author":"Armstrong RW","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008893109257"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.022616"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp239"},{"key":"e_1_2_7_10_1","first-page":"1100","article-title":"Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1","volume":"12","author":"Cho E\u2010Y","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21857"},{"key":"e_1_2_7_12_1","first-page":"1432","article-title":"[Letter: Idiopathic hemochromatosis associated with HL\u2010A 3 tissular antigen]","volume":"4","author":"Simon M","year":"1975","journal-title":"La Nouvelle presse medicale"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.07.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.601"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003103"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20946"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.23.1780"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-7772.2001.00529.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.109"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1885"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.49"},{"key":"e_1_2_7_22_1","volume-title":"Current protocols in molecular biologyed","author":"Ausubel FM","year":"1987"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2088"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046688"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.86"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr917"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg108"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp950"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.024"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162327"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq452"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174148"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04768"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.01.001"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.674"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/345041a0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1229"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq929"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0504-431"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.12.005"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1452"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:01:33Z","timestamp":1696356093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/ijc.29035"],"URL":"https:\/\/doi.org\/10.1002\/ijc.29035","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}