{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:42:53Z","timestamp":1769499773600,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006209","name":"Radboud university medical center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>A history of urinary bladder cancer (UBC) in first\u2010degree relatives increases UBC risk by twofold. The influence of positive family history on UBC prognosis is unknown. Here, we investigated association of first\u2010degree UBC family history with clinicopathological characteristics and prognosis of UBC patients. Detailed clinical data of 1,465 non\u2010muscle\u2010invasive bladder cancer (NMIBC) and 250 muscle\u2010invasive or metastatic bladder cancer (MIBC) patients, diagnosed from 1995 to 2010, were collected through medical file review. Competing risk analyses were used to compare recurrence\u2010free survival (RFS) and progression\u2010free survival (PFS) of NMIBC patients according to self\u2010reported UBC family history. Overall survival in MIBC patients was estimated using Kaplan\u2010Meier analysis. The added value of family history in prediction of NMIBC prognosis was quantified with Harrell's concordance\u2010index. Hundred (6.8%) NMIBC and 14 (5.6%) MIBC patients reported UBC in first\u2010degree relatives. Positive family history was statistically significantly associated with smaller tumor size and non\u2010significantly with more favorable distribution of other tumor characteristics. In univariable analyses, positive family history correlated with longer RFS (<jats:italic>p =<\/jats:italic> 0.11) and PFS (<jats:italic>p =<\/jats:italic> 0.04). Hazard ratios for positive <jats:italic>vs<\/jats:italic>. negative family history after adjustment for clinicopathological characteristics were 0.75 (95% CI = 0.53\u20131.07) and 0.45 (95% CI = 0.18\u20131.12) for RFS and PFS, respectively. Five familial and 48 sporadic MIBC patients (Kaplan\u2010Meier 10\u2010year risk: 41% and 25%) died within 10 years. Family history did not improve the c\u2010index of prediction models. This study shows that a first\u2010degree family history of UBC is not clearly associated with NMIBC prognosis. Family history does not aid in prediction of NMIBC recurrence or progression.<\/jats:p>","DOI":"10.1002\/ijc.29062","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T01:43:51Z","timestamp":1404179031000},"page":"1117-1124","source":"Crossref","is-referenced-by-count":18,"title":["The prognostic value of family history among patients with urinary bladder cancer"],"prefix":"10.1002","volume":"136","author":[{"given":"Lieke","family":"Egbers","sequence":"first","affiliation":[{"name":"Department for Health Evidence Radboud university medical center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne J.","family":"Grotenhuis","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud university medical center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja K.","family":"Aben","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud university medical center Nijmegen The Netherlands"},{"name":"Comprehensive Cancer Center the Netherlands Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Alfred Witjes","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud university medical center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambertus A.","family":"Kiemeney","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud university medical center Nijmegen The Netherlands"},{"name":"Department of Urology Radboud university medical center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita H.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud university medical center Nijmegen The Netherlands"},{"name":"Department of Human Genetics Radboud university medical center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancerbase no. 11 [Internet]","author":"Ferlay 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