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In contrast to previously described lines of cultured Burkitt lymphoma cells, there was a first phase of active proliferation of lymphoblasts completely dependent on an autologous fibroblast moiety of the cultures. In a second phase, lymphoblasts able to grow independently in suspension appeared at 8\u201310 weeks and gradually completely repopulated the cultures. Cytological and electron microscope studies showed that the lymphoid cells of the first phase resembled other cultured Burkitt lymphoblasts, and that the cells characteristic of the second phase were somewhat less differentiated. A herpes\u2010type virus, not transmissible in various tissue cultures or in mice, was detected by electron microscopy in some of the cells.<\/jats:p>","DOI":"10.1002\/ijc.2910030202","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T13:00:53Z","timestamp":1171890053000},"page":"171-182","source":"Crossref","is-referenced-by-count":29,"title":["Cultivation and fine structure of virus\u2010bearing lymphoblasts from a second new guinea burkitt lymphoma: Establishment of sublines with unusual cultural properties"],"prefix":"10.1002","volume":"3","author":[{"given":"J. H.","family":"Pope","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G.","family":"Achong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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