{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:02:43Z","timestamp":1705276963115},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":12543,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1972,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism of deciduomata maintenance by 3\u2010methylcholanthrene (MCA) was investigated in normally cycling Sprague\u2010Dawley rats. Animals received daily injections of ovine prolactin (LTH) from days 1\u20104 following estrus (pre\u2010trauma period). On days 5 to 8 (post\u2010trauma period), each rat received either daily injections of LTH, sesame oil intragastrically, or 10 mg 3\u2010methylcholanthrene (MCA) in 1 ml sesame oil intragastrically. Other rats were either adrenalectomized, ovariectomized or hypophysectomized at the time of uterine traumatization on day 4. Results showed that rats which were not treated with LTH but in which the uterus was traumatized did not develop deciduomata, whereas 80% of rats treated with 5 IU LTH during the post\u2010trauma period were positive. Rats receiving 10 IU LTH during the pre\u2010trauma period but untreated during the post\u2010trauma period did not develop deciduomata. However, 27% of rats were positive when fed oil during the post\u2010trauma period. In the second experiment, 1 ml oil prior to and during the pre\u2010trauma period resulted in all negative responses when oil was fed during the post\u2010trauma period. All rats receiving LTH during the pre\u2010trauma period followed by MCA during the post\u2010trauma period were positive. None of the ovariectomized or hypophysectomized rats exhibited deciduomata when treated with MCA during the post\u2010trauma period. However, 75% of the adrenalectomized rats showed positive reactions. These data indicated that MCA effects release of progestin in quantities sufficient to maintain deciduomata and that both the pituitary gland and ovary are essential for this reponse.<\/jats:p>","DOI":"10.1002\/ijc.2910090219","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T13:50:34Z","timestamp":1171893034000},"page":"402-408","source":"Crossref","is-referenced-by-count":2,"title":["Progestin secretion in 3\u2010methylcholanthrene\u2010treated rats"],"prefix":"10.1002","volume":"9","author":[{"given":"Richard C.","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stretton","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0010049"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-28-2-309"},{"key":"e_1_2_1_4_1","first-page":"107","article-title":"Mammary carcinogenesis by 3\u2010methyl\u2010cholanthrene. IV. Effect of pituitary homograft on mammary\u2010gland growth and tumorigenesis","volume":"29","author":"Dao T. L.","year":"1962","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_5_1","first-page":"567","article-title":"Mammary carcinogenesis by 3\u2010methylcholanthrene. I. Hormonal aspects in tumor induction and growth","volume":"23","author":"Dao T. L.","year":"1959","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_6_1","first-page":"115","volume-title":"IXth Biennial Symposium on Animal Reproduction","author":"Grosvenor C. 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Induction of decidual cell reaction in lactogenic hormone treated and in pseudopregnant rats","volume":"45","author":"Von Berswordt\u2010Wallrabe I.","year":"1964","journal-title":"Acta Endocr. (Kbh.)"},{"key":"e_1_2_1_23_1","first-page":"39","article-title":"Influence of gonadotrophic hormones on the decidual cell reaction in intact and in hypophysectomized rats","volume":"49","author":"Von Berswordt\u2010Wallrabe I.","year":"1965","journal-title":"Acta Endocr. (Kbh.)"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-25-3917"},{"key":"e_1_2_1_25_1","first-page":"645","article-title":"Effects of multiple pituitary homografts or progesterone on 7,12\u2010dimethylbenz(a)anthracene\u2010induced mammary tumors in rats","volume":"41","author":"Welsch C. W.","year":"1968","journal-title":"J. nat. 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