{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:11:30Z","timestamp":1759011090625},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":12298,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1972,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article describes a peculiar tumour which originates in the ileocoecal lymph node of the LOU\/Ws1 strain rat. The tumour cells usually have the appearance of very poorly differentiated lymphoid cells showing a tendency to develop ribosome\u2010studded ergastoplasmic membranes. In about 60% of the cases, such tumours synthesize monoclonal immunoglobulins of the IgG or IgA class, or Bence\u2010Jones proteins. These tumours are readily transplantable in isologous hosts or their F hybrids. The great majority of the transplanted growths retain their capacity for immunoglobulin production during many successive passages in vivo.<\/jats:p><jats:p>A scrutiny of older and more recent literature has revealed several descriptions of rat tumours having the same macroscopic and microscopic features as the tumours described here, except for the immunoglobulin\u2010secreting properties which were never tested in the earlier studies.<\/jats:p><jats:p>It is proposed to call this tumour the rat ileocoecal immunocytoma.<\/jats:p>","DOI":"10.1002\/ijc.2910100316","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T13:50:49Z","timestamp":1171893049000},"page":"568-580","source":"Crossref","is-referenced-by-count":89,"title":["Transplantable immunoglobulin\u2010secreting tumours in rats. I. General features of LOU\/Ws1 strain rat immunocytomas and their monoclonal proteins"],"prefix":"10.1002","volume":"10","author":[{"given":"H.","family":"Bazin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Deckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Heremans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Andr\u00e9 C. Bazin H. Beckers A. andHeremans J. F. A quantitative difference in the immune response to sheep red cells between rat strains. Submitted for publication."},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Spontaneous tumors of the rat","author":"Bullock F. D.","year":"1930","journal-title":"J. Cancer Res."},{"key":"e_1_2_1_4_1","unstructured":"Burtonboy G. Bazin H. Beckers A. Deckers C. Lamy M. andHeremans J. F. Manuscript in preparation."},{"key":"e_1_2_1_5_1","first-page":"311","article-title":"Spontaneous tumours in the Rochester strain of the Wistar rat","volume":"34","author":"Crain R. C.","year":"1958","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_6_1","first-page":"67","article-title":"A statistical study of the occurrence of spontaneous tumors in a large colony of rats","volume":"15","author":"Curtis M. R.","year":"1931","journal-title":"Amer. J. Cancer"},{"key":"e_1_2_1_7_1","first-page":"299","article-title":"Transplantable lymphosarcomata of the mesenteric lymph nodes of rats","volume":"40","author":"Curtis M. R.","year":"1940","journal-title":"Amer. J. Cancer"},{"key":"e_1_2_1_8_1","first-page":"105","article-title":"Etude \u00e9lectrophor\u00e9tique et immuno\u00e9lectrophor\u00e9tique des prot\u00e9ines du rat atteint de leucosarcome","volume":"11","author":"Deckers C.","year":"1963","journal-title":"Protides Biol. Fluids"},{"key":"e_1_2_1_9_1","volume-title":"Structure antig\u00e9nique de tumeurs exp\u00e9rimentales","author":"Deckers C.","year":"1964"},{"key":"e_1_2_1_10_1","series-title":"UICC Monograph Series","first-page":"34","volume-title":"specific tumour antigens","author":"Deckers C.","year":"1966"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/S0021-9258(18)93167-4","article-title":"Studies on the conformation of purified human and canine \u03b3A\u2010globulins and equine \u03b3T\u2010globulin by optical rotatory dispersion","volume":"243","author":"Dorrington K. J.","year":"1968","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/19.3.371"},{"key":"e_1_2_1_13_1","first-page":"61","article-title":"The respective roles of longevity and genetic specificity in the occurrence of spontaneous tumors in the hybrids between two inbred lines of rats","volume":"6","author":"Dunning W. F.","year":"1946","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","first-page":"773","article-title":"Spontaneous and transplanted reticulum cell sarcomas in Wistar rats","volume":"20","author":"Farris E. J.","year":"1944","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_15_1","first-page":"257","article-title":"Spontaneous neoplasms in the albino rat","volume":"23","author":"Gilbert C.","year":"1958","journal-title":"S. Afr. med. Sci."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1958.66"},{"key":"e_1_2_1_17_1","volume-title":"Tumeurs spontan\u00e9es des animaux de laboratoire","author":"Gu\u00e9rin M.","year":"1954"},{"key":"e_1_2_1_18_1","first-page":"354","article-title":"Un cas de paraglobulin\u00e9mie chez le chien","volume":"6","author":"Groulade J.","year":"1959","journal-title":"Bull. Acad. V\u00e9t. France"},{"key":"e_1_2_1_19_1","first-page":"407","article-title":"Reticulum cell sarcoma in the rat transferred through twelve successive passages in animals of related stock","volume":"1","author":"Jenney F. S.","year":"1941","journal-title":"Cancer Res."},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4049\/jimmunol.109.3.511","article-title":"Characterization of three homogeneous feline immunoglobulins","volume":"109","author":"Kehoe J. M.","year":"1972","journal-title":"J. Immunol"},{"key":"e_1_2_1_21_1","first-page":"1031","article-title":"A highly inbred line of Wistar rats yielding spontaneous mammo\u2010somatotropic pituitary and other tumors","volume":"24","author":"Kim U.","year":"1960","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_22_1","first-page":"184","article-title":"Occurrence of cancer in rats treated with oestrone","volume":"34","author":"McEuen C. S.","year":"1938","journal-title":"Amer. J. Cancer"},{"key":"e_1_2_1_23_1","first-page":"383","article-title":"The occurrence of lymphosarcoma in rats","volume":"36","author":"McEuen C. S.","year":"1939","journal-title":"Amer. J. Cancer"},{"key":"e_1_2_1_24_1","first-page":"247","article-title":"La radiobiologie comme m\u00e9thode de travail en physiopathologie et en canc\u00e9rologie exp\u00e9rimentale","volume":"11","author":"Maisin J.","year":"1955","journal-title":"Bull. Acad. Suisse Sci. med."},{"key":"e_1_2_1_25_1","first-page":"346","article-title":"Syndromes mortels et effects tardifs des irradiations totales et subtotales chez le rat","volume":"40","author":"Maisin J.","year":"1957","journal-title":"J. belge Radiol."},{"key":"e_1_2_1_26_1","first-page":"341","volume-title":"Symp. Lymph. Tumours in Africa, Paris","author":"Maisin J.","year":"1964"},{"key":"e_1_2_1_27_1","first-page":"1052","article-title":"Au sujet de l'influence canc\u00e9rig\u00e8ne de l'irradiation in toto \u00e0 dose unique","volume":"149","author":"Maisin J.","year":"1955","journal-title":"C. R. Soc. Biol. (Paris)"},{"key":"e_1_2_1_28_1","first-page":"571","article-title":"Le leucosarcome chez le rat. L'incidence de ce n\u00e9oplasme apr\u00e8s irradiation totale, subtotale et locale","author":"Maldague P.","year":"1958","journal-title":"Sang"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00525558"},{"key":"e_1_2_1_30_1","first-page":"297","article-title":"Neoplasms in rats treated with pituitary growth hormone. I. Pulmonary and lymphatic tissues","volume":"10","author":"Moon H. D.","year":"1950","journal-title":"Cancer Res."},{"key":"e_1_2_1_31_1","first-page":"704","article-title":"Identification and characterization of three spontaneous myeloma proteins in Wistar rats","volume":"29","author":"Nash D. R.","year":"1970","journal-title":"Fed. Proc."},{"key":"e_1_2_1_32_1","first-page":"578","article-title":"Reticulum cell lymphosarcoma in rats","volume":"31","author":"Nelson A. A.","year":"1941","journal-title":"Arch. Pathol."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-94-22035"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","unstructured":"Querinjean P. Bazin H. Beckers A. Deckers C. andHeremans J. F. Transplantable immunoglobulin\u2010secreting tumours in rats. II. Characterization of kappa type L\u2010chains from LOU\/Wsl rats.Europ. J. Biochem. in press (1972).","DOI":"10.1111\/j.1432-1033.1972.tb02540.x"},{"key":"e_1_2_1_35_1","unstructured":"Querinjean P. andMilsteinC.Kappa\u2010type immunoglobulin light chains of rat strain LOU\/Wsl.Prot. Biol. Fluids. In press (1972)."},{"key":"e_1_2_1_36_1","first-page":"553","article-title":"Spontaneous reticular neoplasms in (CBA x DBA\/2)F1 mice, with special emphasis on the occurrence of plasma cell neoplasms","volume":"43","author":"Rask\u2010Nielsen R.","year":"1969","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_37_1","first-page":"237","article-title":"Spontaneous tumors in two colonies of rats of the Wistar Institute of Anatomy and Biology","volume":"26","author":"Ratcliffe H. L.","year":"1940","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_38_1","first-page":"17","article-title":"Les lymphosarcomes du rat","volume":"30","author":"Roussy G.","year":"1942","journal-title":"Bull. Ass. Fran\u00e7. Et. Cancer."},{"key":"e_1_2_1_39_1","first-page":"423","article-title":"The influence of nutrition upon the incidence of spontaneous tumors of the albino rat","volume":"6","author":"Saxton J. A.","year":"1948","journal-title":"Acta Un. int. Cancr."},{"key":"e_1_2_1_40_1","first-page":"1","volume-title":"Pathology of laboratory animals","author":"Snell K. C.","year":"1964"},{"key":"e_1_2_1_41_1","first-page":"59","article-title":"Hematopoietic neoplasms of rats and mastomys","volume":"32","author":"Snell K. C.","year":"1968","journal-title":"Nat. Cancer. Inst. Monograph"},{"key":"e_1_2_1_42_1","first-page":"37","article-title":"Pathologic anatomy of chronic ulcerative cecitis: a spontaneous disease of the rat","volume":"31","author":"Stewart H. L.","year":"1941","journal-title":"Arch. Path."},{"key":"e_1_2_1_43_1","first-page":"1037","article-title":"Spontaneous tumors in the Sprague\u2010Dawley rat","volume":"27","author":"Thomson S. W.","year":"1961","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_44_1","first-page":"1535","article-title":"Apparition de tumeurs malignes dans une lign\u00e9e de rats \u201cWistar\u201d","volume":"254","author":"Tuchmann\u2010Duplessis H.","year":"1962","journal-title":"C. R. Acad. Sci. (Paris)"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.154.3751.901"},{"key":"e_1_2_1_46_1","first-page":"205","article-title":"Notes on twenty\u2010two spontaneous tumors in wild rats","volume":"25","author":"Woolley P. G.","year":"1911","journal-title":"(M. Norvegicus). J. med. Res."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910100316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910100316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T10:34:27Z","timestamp":1699785267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910100316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,11,15]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,11,15]]}},"alternative-id":["10.1002\/ijc.2910100316"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910100316","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,11,15]]}}}